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Supplier: Ambeed
Description: SNS-314 mesylate ≥98%

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Supplier: Adipogen
Description: Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. The role of Aurora C is unclear; however, Aurora C can complement Aurora B kinase activity in mitosis. SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. A cocrystal structure of SNS-314 with Aurora A confirms that SNS-314 engages the purine-binding pocket of Aurora. SNS-314 inhibits cellular proliferation in the HCT116 colorectal carcinoma cell line with an EC50 of ~5nM. Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. Administration of SNS-314 to HCT116 tumor bearing mice potently suppresses tumor growth. Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent.

Supplier: Thermo Scientific Chemicals
Description: 7-Ethyl-10-hydroxycamptothecin 98%

Supplier: Ambeed
Description: 7-Ethyl-10-hydroxycamptothecin 98%

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Supplier: Ambeed
Description: 4-((S)-2-(4-Aminobutyl)-35-(4-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxamido)methyl)-1H-1,2,3-triazol-1-yl)-4,8-dioxo-6,12,15,18,21,24,27,30,33-nonaoxa-3,9-diazapentatriacontanamido)benzyl ((S)-4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl) carbonate ≥98%

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Supplier: TCI America
Description: CAS Number: 86639-52-3
MDL Number: MFCD06762720
Molecular Formula: C22H20N2O5
Molecular Weight: 392.41
Purity/Analysis Method: >98.0% (HPLC)
Form: Crystal
Melting point (°C): 217
Specific rotation [a]20/D: 21.5 deg (C=0.2, THF)
Supplier: Ambeed
Description: Gabexate mesylate 98%

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Supplier: Thermo Scientific Chemicals
Description: Imatinib mesylate 98%

Supplier: Thermo Scientific Chemicals
Description: Gemifloxacin mesylate

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Supplier: Ambeed
Description: Rasagiline mesylate 97%

Supplier: TCI America
Description: Dolasetron Mesylate monohydrate ≥98.0% (by HPLC)

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Supplier: TCI America
Description: Eprosartan Mesylate, Purity: >98.0%(HPLC)(T), CAS Number: 144143-96-4, Molecular Formula: C23H24N2O4S.CH4O3S, Molecular Weight: 520.62, Synonym: Eprosartan Methanesulfonate, Physical state: Solid, Form: Crystal- Powder, Colour: White - Almost white, Size: 1G

SDS

Supplier: Ambeed
Description: Eprosartan Mesylate 99%

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Supplier: Thermo Scientific Chemicals
Description: Coumarin 314 99%, pure

Supplier: Matrix Scientific
Description: MF=C17H22N2O3S MW=334.44 MDL=MFCD20489148 1G

Supplier: Ambeed
Description: (S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride ≥97%

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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