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Catalog Number: (77620-874)
Supplier: Ambeed
Description: BMS-8 98%

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Supplier: Adipogen
Description: BMS-599626 is an orally bioavailable, highly selective and potent pan-HER kinase inhibitor. It inhibits HER1 and HER2 with IC(50) values of 20 and 30nM, respectively.

Supplier: Ambeed
Description: BMS-582949 ≥98%

New Product

Supplier: Adipogen
Description: BMS-2 is a potent MET kinase inhibitor with an IC(50) value of 1.8nM. It also possesses potent inhibitory activity against Flt-3 and VEGFR-2 kinases, IC(50) values of 4nM and 27nM respectively.

Supplier: Ambeed
Description: BMS-599626 hydrochloride 98+%

New Product

Supplier: Adipogen
Description: BMS-540215 is an ATP-competitive inhibitor of human VEGFR-2, with an IC(50) of 25nM and Ki of 26nM. BMS-540215 also showed good selectivity for FGFR-1 (IC(50) of 48nM), FGFR-2 (IC(50) of 125nM), and FGFR-3 (IC(50) of 68nM).

Supplier: Ambeed
Description: BMS-708163 98+%

Supplier: Ambeed
Description: Brivanib (BMS-540215) 96%

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Supplier: Ambeed
Description: BMS-626529 98%

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Supplier: Ambeed
Description: BMS-303141 98%

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Supplier: Ambeed
Description: BMS-863233 hydrochloride ≥98%

New Product

Supplier: Adipogen
Description: Kinases, such as LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2), have been identified as participating in signal pathways affecting actin dynamics by deactivating cofilin. Over expression of LMK1 has been found in invasive breast and prostate cancer cell lines and suppression of LIMK 2 expression has been found to limit migration of human fibrosarcoma cells. Thus, the inhibition of LIMK1 and/or LIMK2 enzymes have been suggested as targets for treating cancer, including reduction or prevention of metastasis. BMS-5 is a potent inhibitor of the LIM kinase. It has IC(50) values of 7nM and 8nM for LIMK1 and LIMK2 respectively. LIMK1/2 activity was measured via TCA precipitation assay using a biotinylated ADF (actin depolymization factor) as the protein substrate and the kinase domains of LIMK1 and LIMK2 as the enzyme sources in the presence of 1µM ATP.

Supplier: Adipogen
Description: BMS387032 is a novel cyclin-dependent kinase inhibitor, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. It inhibits CDK2 with an IC(50) of 48nM and up to 20-fold selective over CDK1/CDK4. It also inhibits CDK7/9 with IC(50) values of 62nM and 4nM. It has little effect on CDK6.

Supplier: Adipogen
Description: BMS-3 is a potent inhibitor of the LIM kinase. It has IC(50)'s of 5nM and 6nM for LIMK1 and LIMK2 respectively.

Supplier: Ambeed
Description: BMS-777607 98%

New Product

Supplier: Cayman Chemical Company
Description: BMS 345541 (trifluoroacetate salt), Purity >/=98%, MF: C14H17N5.2CF3COOH, MW: 483.4, Synonyms: IKK Inhibitor III, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine, trifluoroacetate salt, Formulation: crystalline, Storage: -20C, Size: 10mg

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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