You Searched For: Diagnostic Biosystems

Supplier: Diagnostic Biosystems

Description: BRCA1 recognizes a 22kDa protein. This antibody stains 94% of ovarian carcinomas with a mutation in exon 11. However, staining was absent in 100% of tumors with mutations other than exon 11.

Catalog Number: (95027-202)

Supplier: Diagnostic Biosystems

Description: This kit stains myelin sheath and Nissl substance in paraffin tissue sections

Catalog Number: (99990-076)

Supplier: Diagnostic Biosystems

Description: Proper tissue adhesion to the glass slides is critical in the immunostaining process. Improper adhesion of tissue sections can lead to poor quality staining or even loss of tissue sections during the process of immunostaining. White glue, albumen, chromegelatin and poly-L-lysine are used as tissue adhesives.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 92 kDa pro form and 86 kDa active form of MMP-9. MMPs are proteolytic enzymes capable of degrading connective tissue components. MMPs play a crucial role in tumor cell invasion and metastasis.

Supplier: Diagnostic Biosystems

Description: Monoclonal anti-bcl-10 reacts specifically with human bcl-10. The epitope recognized by the antibody resides within amino acids 122-168 of human bcl-10 molecule. Bcl-10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (caspase recruitment domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl-10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl-10 cellular overexpression induces JNK, p38, and NF-kB activation. Deregulation of bcl-10 expression was also demonstrated to be involved in cellular oncogenesis.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with human myeloperoxidase. It stains granules of neutrophils, granulocytes in spleen, bone marrow, tonsil and blood smears.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 55 kDa protein. Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response in insulin and IGF-1 induced signaling. GLUT-1 is detectable in many human tissues including those of the colon, lung, stomach, esophagus and breast. GLUT-1 immunoreactivity in some cancers, including trans-carcinoma of the urinary bladder, has been associated with aggressive behavior.

Supplier: Diagnostic Biosystems

Description: This antibody stains with ORF-73 of human herpesvirus 8 (HHV8). HHV8 is the likely etiological agent of Kaposi sarcoma (KS). HHV8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene ORF 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity.

Supplier: Diagnostic Biosystems

Description: This antibody reacts specifically with sialyl Lewisa and recognizes an epitope being designated CA 19-9. It does not cross-reacts with Lewisa and Lewisb. CA 19-9 has been shown to be useful marker in the diagnosis and management of gastrointestinal cancers.

Supplier: Diagnostic Biosystems

Description: Anti-CD10 Calla Mouse Monoclonal Antibody [clone: 56C6]

Supplier: Diagnostic Biosystems

Description: MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-base mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.

Catalog Number: (95029-782)

Supplier: Diagnostic Biosystems

Description: The CD163 molecule is a type I membrane protein also known as M130 antigen, Ber-Mac3, Ki-M8 or SM4

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a cluster of proteins between 19-22 kDa (reduced). VEGF is a homodimeric disulfide-linked glycoprotein involved in angiogenesis, which promotes tumor progression and metastasis. It exhibits potent mitogenic and permeability-inducing properties specific for the vascular endothelium.

Supplier: Diagnostic Biosystems

Description: α-fetoprotein (AFP) is a single chain glycoprotein of 70 kDa that is normally expressed in the fetal liver, gastrointestinal tract and yolk sac. This antibody recognizes an epitope of α-fetoprotein present in human and several other species.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with desmin protein of 53 kDa. Both striated as well as smooth muscle cells stain well with this antibody. The antibody shows a broad interspecific cross-reactivity, reacting with human.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a glycoprotein of MW 110 kDa, present on the surface of hematopoietic cells i.e. myeloid and lymphoid progenitors. It stains the vascular endothelial cells.