You Searched For: Diagnostic Biosystems

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a protein of 81 kDa. Ezrin serves as a tyrosine kinase substrate and is phosphorylated in EGF-stimulated cells. Ezrin is a cytoplasmic protein, enriched in microvilli and other cell surfaces. Ezrin has an actin-binding capacity. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a protein of 57 kDa known as p57Kip2 a cell cycle regulatory mitotic inhibitor. This antibody does not cross-react with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes and a negative regulator of cell proliferation.

Catalog Number: (76633-070)

Supplier: Diagnostic Biosystems

Description: 23347679

Catalog Number: (76634-518)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with herpes simplex virus type 2. It is specific for the viral glycoprotein D (gD) protein.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with the whole <i>H. pylori</i>. The antibody stains the bacteria present on the surface of the epithelium or in the cytoplasm of the epithelial cells. <i>H. pylori</i> is known to cause peptic ulcer and chronic gastritis in humans.

Catalog Number: (76634-516)

Supplier: Diagnostic Biosystems

Description: Galectin-3 is a member of the beta-galactoside-binding protein family that plays an important role in cell adhesion, cell matrix interactions, macrophage activation, angiogenesis, metastasis, and apoptosis.

Galectin-3 shows strong diffuse cytoplasmic staining in most cases of papillary thyroid carcinoma (PTC), most poorly differentiated thyroid cancers demonstrate galectin-3 protein expression while it is not expressed in anaplastic thyroid cancers. (1) Upregulated expression of galectin-3 is involved in cancer progression and metastasis, and it is suggested that Galectin-3 may be a valuable tool to support diagnosis of parathyroid carcinoma. (2)

Galectin-3 has also been reported to play important roles in the progression of prostate cancer, and their heterogeneous expressions might be associated with different cancer subtypes. (3)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 95 to 100 kDa protein. This antibody recognizes amyloid precursor proteins APP695, APP751 and APP770. Amyloid precursor protein and APP-like proteins are transmembrane glycoproteins with a similar modular domain structure.

Supplier: Diagnostic Biosystems

Description: The mammaglobin gene was first identified using a differential screening approach directed at the isolation of novel, human breast cancer-associated genes. Mammaglobin-A is highly overexpressed in breast cancer cell lines and primary breast tumors. This pattern of expression is restricted to mammary epithelium and metastatic breast tumors. Thus, mammaglobin-A-specific T cell immune responses may provide an important approach for the design of breast cancer-specific immunotherapy.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 38 kDa protein. Synaptophysin is an glycoprotein occurring in presynaptic vesicles of neurons in the brain, spinal cord, retina, vesicles of adrenal medulla and in neuromuscular junctions. This antibody reacts with neuroendocrine neoplasms of neural as well as epithelial types.

Catalog Number: (76634-388)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 50 kDa cytokeratin protein designated cytokeratin 14. Cytokeratin 14 belongs to the type A (acidic) subfamily of low molecular weight cytokeratins and exists in combination with cytokeratin 15. This antibody can be used to distinguish stratified epithelial cells from simple epithelial cells.

Supplier: Diagnostic Biosystems

Description: PRAME (Preferentially expressed Antigen in Melanoma) is a tumorassociated antigen and is a member of the family of cancer testis antigens (CTA). PRAME is expressed in malignant cells, including leukaemias, Hodgkin's lymphoma, breast cancer, and primary and metastatic melanomas. PRAME has low or no expression in normal tissues except for in testis, ovary, placenta, adrenals and endometrium.

Catalog Number: (76634-394)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 160 kDa protein known as Factor XIII-A. Factor XIII is a β-globulin found in plasma and is composed of two subunits, Factor XIII-A and Factor XIII-B. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160 kDa. Factor XIII is a dermal dendrocyte marker and v variable reaction with these types of tumors.

Catalog Number: (76634-390)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with cytokeratin 5 intermediate filament protein. Basal cells of human epidermis express acidic cytokeratin 14 and basic cytokeratin 5. Cytokeratin 5 is a 58 kDa protein, which is closely related to cytokeratin 6. Cytokeratin 5 and 6 are expressed in basal cell epithelioma, basal cells of prostate, urothelium, vagina, squamous cell carcinomas of skin, tongue, epiglottis and rectal-anal region. Cytokeratin 5 can be useful in the distinction of mesotheliomas from most adenocarcinomas.

Supplier: Diagnostic Biosystems

Description: Epithelial antigen is a cell surface glycoprotein and is broadly distributed in epithelial cells and displays a highly conserved expression in carcinomas. Epithelial antigen has been shown to play an important role as a tumor cell marker in lymph nodes from patients with esophageal carcinoma. Epithelial antigen can be used to distinguish between basal cell and basosquamous carcinomas and squamous cell carcinoma of the skin.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 77-85 kDa protein known as transglutaminase II (TGase II). TGase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. Different tissue and cell types express varying amounts of tissue transglutaminase.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 45-60 kDa proteins identified as tau proteins. This antibody does not cross react with tubulin or other microtubule associated proteins. This antibody recognizes a phosphorylation-independent epitope in amino acids 404 to 441 (human). Tau antibody stains human neurofibrillary tangles, neutrophil threads and neurotic plaques associated with Alzheimer’s disease.