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Description: TRC Topotecan Hydrochloride
Catalog Number: 77994-505
Supplier: LGC Standards

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Description: Topotecan hydrochloride 98%
Catalog Number: 77599-772
Supplier: Ambeed

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Description: Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin. Used in chemotherapy of several different cancers.
Catalog Number: 89149-142
Supplier: Enzo Life Sciences


Description: TRC N-Desmethyl Topotecan
Catalog Number: 77981-986
Supplier: LGC Standards

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Description: Topotecan ≥98%
Catalog Number: 77671-058
Supplier: Ambeed

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Description: Pharmaceutical Standards, (R)-Topotecan
Catalog Number: 77546-972
Supplier: TLC Standards

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Description: Pharmaceutical Standards, Topotecan
Catalog Number: 77475-346
Supplier: TLC Standards

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Description: Organic Standard, Topotecan-d6
Catalog Number: 77695-238
Supplier: LGC Standards

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Description: Pharmaceutical Standards, Topotecan-d6 DiHCl
Catalog Number: 77475-350
Supplier: TLC Standards


Description: Trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by camptothecin (80055-998) and topotecan in HL-60 cells. Heavy metals: <=10ppm.
Catalog Number: 80055-528
Supplier: MilliporeSigma

Description: An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
Catalog Number: 77436-882
Supplier: Bioss


Description: MRP4 transports cyclic nucleotides and anti-retroviral compounds and may be an organic anion pump relevant to cellular detoxification. It is widely expressed, with particularly high levels in prostate, but is barely detectable in liver. It belongs to the ATP binding cassette (ABC) transporter family. MRP4 confers resistance to topotecan and acts as a double agent in protecting the brain from chemotherapy.
Catalog Number: 89367-424
Supplier: Genetex


Description: An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
Catalog Number: 77437-636
Supplier: Bioss


Description: L-Arginine Hydrochloride, Multi-Compendial
Catalog Number: MK4930-09
Supplier: AVANTOR PERFORMANCE MATERIALS US

Description: Guanidinium hydrochloride, Proteomics Grade
Catalog Number: 97063-766
Supplier: VWR

Description: L(+)-Cysteine hydrochloride monohydrate, high purity
Catalog Number: 97061-206
Supplier: VWR

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