You Searched For: VX-702

Supplier: Ambeed

Description: VX-702 ≥99%

New Product

Supplier: Adipogen

Description: The kinases called p38 MAP kinases (MAPKs) are intracellular, soluble serine-threonine kinases which belong to a large family of proteins that include the extracellular regulated kinases (ERKs) and c-Jun N-terminal kinases (JNKs). So far four p38 isoforms have been identified, namely p38alpha, p38beta, p38gamma and p38delta, a.k.a. p38-alpha (MAPK14), -beta (MAPK11), -gamma (MAPK12 / ERK6), and -delta (MAPK13 / SAPK4). The ubiquitously expressed s p38alpha has been the most extensively studied and is believed to be the most physiologically relevant in the regulation of the inflammatory response. The role of the three other isoforms is not currently well understood, however their primary sites of expression are known. Similar to p38alpha, p38beta is also ubiquitously expressed, while p38gamma is expressed predominately in skeletal muscle and p38delta is expressed primarily in the lung, kidney, testis, small intestine and pancreas. The small molecule inhibitor VX-702 is a potent p38 kinase family inhibitor that has been studied for its effects on inflammation and the inflammatory response. VX-702 dose-dependently inhibited the production o IL-6, IL-1beta and TNFalpha (IC(50) = 59, 122 and 99ng/ml, respectively), and in anti-platelet aggregation assays, pre-incubation of platelets with VX-702 (1µM)completely or partially inhibited platelet agonist induced p38 activation (IC(50) = 4 to 20nM). More recently VX-702 has been studied as a potential treatment for rheumatoid arthritis (RA). VX-702 appears to be most effective against MAPK14, followed by MAPK11 and the remaining members of the family, however exact in vitro IC(50) values have not been published. However a large amount of data is available for in vitro growth inhibition assays where VX-702 exhibits poptent activity, having low IC(50) values beginning at ~16nM and ending at < 400µM for the numerous cell lines tested.

Catalog Number: (97019-050)

Supplier: VWR International

Description: For Use On 11X14In Universal Platform 89027-702 & Standard And Advanced Models 3500, 3750, * Incubating Orbital Shaker 980153 Tray.

Supplier: Adipogen

Description: VX745 is a selective inhibitor of p38alpha with an IC(50) of 10nM.

Supplier: Ambeed

Description: (S)-1-((S)-2-(4-Amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide, Purity: 99%, CAS Number: 273404-37-8, Appearance: White to Yellow Solid, Storage: Keep in dark place, Inert atmosphere, 2-8 C, Size: 1mg

Supplier: Ambeed

Description: 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one, Purity: 98%, CAS Number: 209410-46-8, Appearance: Form: powder, Storage: Sealed in dry, Store in freezer, under -20 deg C, Size: 10mg

Supplier: Ambeed

Description: VX-661 ≥99%

New Product

Supplier: Ambeed

Description: (S)-4-(2-((2-Chloro-4-fluorophenyl)amino)-5-methylpyrimidin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide, Purity: 98%, CAS Number: 896720-20-0, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20 C, Size: 10mg

Supplier: Ambeed

Description: Decernotinib (VX-509) 98+%

New Product

Catalog Number: (90002-556)

Supplier: BD

Description: BD Taxo™ X Factor Discs are used for differentiating <i>Haemophilus</i> species.

Certificates

Supplier: Matrix Scientific

Description: CAS: 702-82-9 MDL Number: MFCD01821204 Molecular Formula: C10H17NO Molecular Weight: 167,25 Hazard: Irritant

Catalog Number: (76763-408)

Supplier: Prosci

Description: Anti-VX-15 Recombinant Antibody

Supplier: BD

Description: Supplement VX with Reconstituting Fluid is used for supplementing media to culture fastidious microorganisms, particularly Neisseria gonorrhoeae and Haemophilus influenzae.

SDS Certificates

Supplier: Matrix Scientific

Description: MF=C9H16N2 MW=152.24 Cas=702-03-4 MDL=MFCD00021325 5G

SDS

Supplier: Adipogen

Description: Tozasertib, or VX-680, is a potent and selective inhibitor of Aurora kinases, particularly Aurora A and B. In vitro, VX-680 blocks cell cycle progression and induces apoptosis in a wide range of human tumor types at low IC(50) values (i.e. 3.38nM for human BE-13 cells, and 14.34nM for NTERA cells). Moreover, VX680, also has very potent Ki values, with inhibition constants (Ki) of 0.6, 18, and 46nM for Aurora A, B, and C, respectively. VX-680 is also effective in vivo, being used in a Caki-1 xenograft model, VX-680 demonstrated a 75.7% (P < 0.001) decrease in Caki-1 xeno-graft tumor volume with no apparent alternation in animal body weight, peripheral blood counts, or other biological parameters.

Supplier: BD

Description: Use with Hemoglobin or Hemoglobin 2%, Antimicrobic Vial CNV or CNVT, Supplement A, B, C or VX

SDS Certificates