You Searched For: SAR-131675


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Supplier: Adipogen
Description: SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45nM, respectively. SAR131675 dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC(50) of about 20nM. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. However, it was moderately active on VEGFR-2 with a VEGFR-3/VEGFR-2 ratio of about 10. SAR131675 had no antiproliferative activity on a panel of 30 tumors and primary cells, further showing its high specificity and indicating that SAR131675 is not a cytotoxic or cytostatic agent.

Supplier: Ambeed
Description: (-)-2-Amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide, Purity: 95+%, CAS Number: 1092539-44-0, Appearance: White to off-white solid, Storage: Keep in dark place, Sealed in dry, Store in freezer, under -20 deg C, Size: 1mg

Supplier: Adipogen
Description: SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo.

Supplier: Bachem Americas
Description: Sequence: Z-Sar-OSu

Supplier: Ambeed
Description: Z-Gly-Sar-OH, Purity: 98%, CAS Number: 7801-91-4, Appearance: Solid, Storage: Keep in dark place, Sealed in dry, Store in freezer, under -20C, Size: 1G

Supplier: Ambeed
Description: Fmoc-Sar-OH, Purity: 98% HPLC, CAS Number: 77128-70-2, Appearance: Form: Powder/Colour: White - Yellow, Storage: Keep in dark place, Sealed in dry, Room Temperature, Size: 500g

Supplier: Bachem Americas
Description: Sequence: Fmoc-Sar-OH

Supplier: Matrix Scientific
Description: Matrix Scientific Part Number: 042464-25G , MDL Number: MFCD00151926

Supplier: Matrix Scientific
Description: MF=C18H19NO5 MW=329.36 CAS=77128-70-2 MDL=MFCD00180724 100G

Supplier: Ambeed
Description: 2-(2-Chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide, Purity: 98%, CAS Number: 1450881-55-6, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, Room temperature, Size: 25mg

Supplier: Thermo Scientific Chemicals
Description: N-Fmoc-N-methylglycine, 98%
Supplier: Ambeed
Description: 1-(6-((6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)thio)benzo[d]thiazol-2-yl)-3-(2-morpholinoethyl)urea, Purity: 98+%, CAS Number: 1116743-46-4, Appearance: White to yellow powder or crystals, Storage: Keep in dark place, Inert atmosphere, 2-8 C, Size: 10mg

Supplier: TCI America
Description: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine, Purity: >98.0%(HPLC)(T), CAS number: 77128-70-2, Molecular Formula: C18H17NO4, Molecular Weight: 311.34, Synonym: Fmoc-N-Me-Gly-OH, N-Fmoc-N-methylglycine, Size: 5G

Catalog Number: (103888-866)
Supplier: ACROBIOSYSTEMS INC MS
Description: This kit is developed for detecting SARS-CoV-2 Spike RBD in the sample.


Catalog Number: (103888-720)
Supplier: ACROBIOSYSTEMS INC MS
Description: This kit is developed for serologic test for IgG4 titer of Anti-SARS-CoV-2 antibody in serum/plasma <i>in vitro</i>.


Catalog Number: (103888-724)
Supplier: ACROBIOSYSTEMS INC MS
Description: This kit is developed for serologic test for IgG2 titer of Anti-SARS-CoV-2 antibody in serum/plasma <i>in vitro</i>.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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