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3,3'-Dipropylthiacarbocyanine iodide

Supplier: Adipogen
Description: Carbocyanine dyes, particularly thiacyanines such as DiSC3(3) can inhibit respiration and may therefore be relatively cytotoxic. 3,3'-dipropyl-thiadicarbocyanine iodide is sensitive to membrane potential, fluorescence response to depolarization depends on the staining concentration and detection method. Selected applications are: -Calcium channels and other ion transport systems -Mitochondrial activity -Neurons and brain tissue -Membrane potential in intact yeast cells

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Bisindolylmaleimide IX·methanesulfonate ≥98% (by NMR)

Supplier: Adipogen
Description: Selective and cell permeable protein kinase C (PKC) inhibitor. Inhibits the stimulation of insulin secretion by glucose. Inhibits T cell activation. Apoptosis inducer. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Transcription inhibitor. Induces TNF receptor family-mediated cell death. Pim-1 kinase inhibitor. Antitumor compound.

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6-ECDCA ≥95% (by NMR)

Supplier: Adipogen
Description: Potent and selective FXR agonist (EC50= 99nM). Induces SHP in HSCs to suppress TIMP-1 expression. Apoptosis inducer. Protects against liver fibrosis development in rat in vivo. Displays anticholeretic activity in rat in vivo. Promotes preadipocyte differentiation. Regulates adipogenesis and insulin signaling in vivo. Inhibits vascular smooth muscle cell inflammation and migration.

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Dichloromethane-[D₂] (99.9% D) (Isotopic) for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00000882

SDS Certificates

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p-Xylenol Blue

Supplier: Adipogen
Description: Sulfonephthalein dye. Acid-base pH indicator dye with pH ranges of pH 1.2 (Red) - pH 2.8 (Yellow), and pH 8.0 (Yellow) - pH 9.6 (Blue). Spectral data: Absorption, lambdamax 424nm. Has been used as pH sensor, indicator, in cosmetics and drug applications, microbiological assays and determining lipases.

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Chloroform-[D₁] (100% D) (Isotopic) + 0.03% v/v TMS for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00000827 Notes: Minimum isotopic purity 99.96%

SDS Certificates

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Splitomicin ≥98% (by NMR)

Supplier: Adipogen
Description: Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells.

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cis-Platin Pt ≥ 64.5% for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: Potent anticancer agent that blocks DNA synthesis

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C646 ≥98% (by NMR)

Supplier: Adipogen
Description: Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor. Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<lt/>10%). Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines.

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Cytochalasin H

Catalog Number: (102989-048)
Supplier: Adipogen
Description: Potent mycotoxin. Phytotoxin. Actin polymerization inhibitor. Used in actin polymerization and cytoskeletal reorganization studies. Antibacterial, antifungal, nematocidal and antitumor compound. Apoptosis inducer. Anti-angiogenic agent. Shows immunosuppressive activity. Shown to modulate the CNS with potential anti-parkinson activity.
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PJ-34 ≥98% (by NMR)

Supplier: Adipogen
Description: Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor. Inhibits peroxynitrite-induced cell necrosis. Shows significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models. Provides cardioprotection by decreasing myocardial infarct size. Shows protective effects in models of stroke. Suppresses cell growth in liver cancer cells.

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(R)-3-Hydroxymyristic acid ≥98% (by NMR)

Supplier: Adipogen
Description: Hydroxy fatty acid used to study its role in biological processes such as oxidative stress, inflammation and insulin resistance. Used in endotoxin and lipid A research, since it is one of two major components of bacterial Lipid A. Shows antifungal activity. Compound could be used as analytical reference in assaying food samples.

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Bisindolylmaleimide I·hydrochloride ≥98% (by NMR)

Supplier: Adipogen
Description: Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.

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Image Unavailable-AA42263-SA

Acetone-[D₆] (100% D) (Isotopic) + 0.03% v/v TMS for NMR spectroscopy

Catalog Number: (AA42263-SA)
Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00044635 Notes: Minimum isotopic purity 99.96%

SDS Certificates


Product Image-102515-712

α-Galactosylceramide ≥96% (by NMR)

Supplier: Adipogen
Description: Synthetic. Originally isolated from the marine sponge <i>Angelas mauritianus</i>. Immunostimulant. Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells. Protects against LPS-induced shock. Potent antitumor compound.

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SMI-4a ≥95% (by NMR)

Catalog Number: (102516-222)
Supplier: Adipogen
Description: Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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