Splitomicin ≥98% (by NMR)

Supplier: ADIPOGEN CORP MS

Synonyms: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one, 1,2-Dihydro-3H-benzo[f]chromen-3-one

AG-CR1-0088-M001 AG-CR1-0088-M005 AG-CR1-0088-M025
102516-132EA 34.62 USD
102516-132 102516-134 102516-136
Splitomicin ≥98% (by NMR)
Splitomicin

Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells.

Formula: C₁₃H₁₀O₂
MW: 198.22 g/mol
Storage Temperature: Freezer
MDL Number: MFCD08705254
CAS Number: 5690-03-9

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Specification Test Results

Purity 98% (NMR)
Appearance/Color White to off-white solid.
Solubility Soluble in methanol, ethanol or DMSO.

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