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Supplier: Adipogen
Description: AMG-458 is a potent inhibitor of c-Met with an IC(50) of 60nM and displays selectivity against VEGFR2.

Catalog Number: (77620-064)
Supplier: Ambeed
Description: AMG-510 ≥99%

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Supplier: Adipogen
Description: AMG-Tie2-1 is a highly potent, non-selective inhibitor of Tie-2 (IC(50) <lt/>1nM).

Supplier: Adipogen
Description: The lymphocyte-specific kinase (Lck) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation. Selective inhibition of Lck is expected to offer a new therapy for the treatment of T-cell-mediated autoimmune and inflammatory disease. AMG-47 is one of two optimized chemical compounds that has been shown to be extremely effective in vivo and in vitro in inhibiting Lck as well as a number of other receptor tyrosine kinases. In an anti-CD3/ IL-2 mouse model system AMG-47 has been shown to be effective in inhibiting the Lck mediated anti-inflammatory activity (ED50 11 mg/kg; 630nM) in vivo. In multiple other in vitro assays, AMG-47 exhibits subnanomolar inhibition against Lck, and low (<lt/>10nM) inhibition against other hard to inhibit kinases such as KDR and SRC and MAPK alpha (p38alpha). Moreover at slightly higher doses but well under 10µM, AMG-47 effectively inhibits the JNK family of kinases including TYK2 at ~ 1.2µM.

Supplier: Adipogen
Description: AMG-1 is a potent inhibitor of human c-Met and RON with IC(50) values of 4 and 9nM respectively.

Supplier: Enzo Life Sciences
Description: TRPV1 antagonist.

Supplier: Ambeed
Description: AMG-900 98%

New Product

Supplier: Ambeed
Description: AMG-1 98%

New Product

Supplier: Adipogen
Description: AMG-25 exhibits potent inhibition of c-Kit with greater than 200-fold selectivity over KDR, p38, Lck and Src.

Supplier: ALADDIN SCIENTIFIC CORPORATION
Description: Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

New Product

Catalog Number: (AAJ64202-MB)
Supplier: Thermo Scientific Chemicals
Description: AMG-9810, Cas Number: 545395-94-6, Molecular Formula: C21H23NO3, Molecular Weight: 337.41, Appearance: Solid, Synonym: 2E-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-Propenamide, Size: 25mg

Supplier: Ambeed
Description: 7-Methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline, Purity: 98+%, CAS Number: 1002304-34-8, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, Room temperature, Size: 10mg

Supplier: Ambeed
Description: AMG-9810 98%

New Product

Supplier: Ambeed
Description: 4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide, Purity: 98%, CAS Number: 882663-88-9, Appearance: Pale-yellow or Pale red to Yellow-brown Solid, Storage: Keep in dark place, Sealed in dry, 2-8 C, Size: 5mg

Supplier: Ambeed
Description: (R)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide ≥98%

New Product

Catalog Number: (76754-854)
Supplier: Prosci
Description: Anti-AMG 655 Recombinant Antibody


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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