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Supplier: Ambeed
Description: 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride, Purity: 98%, CAS number: 344458-15-7, Appearance: Form: powder Colour: white - light yellow - brown, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20C, Size: 1MG

Supplier: Thermo Scientific Chemicals
Description: A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase
Supplier: Enzo Life Sciences
Description: Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC50=20nM compared to EC50=200µM of the prototypical PARP inhibitor 3-aminobenzamide). Inhibits peroxynitrite-induced cell necrosis (EC50=20nM). Has significant, dose-dependent, anti-inflammatory effects in a variety of local inflammation models and provides cardioprotection by decreasing myocardial infarct size.

Supplier: Adipogen
Description: Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor. Inhibits peroxynitrite-induced cell necrosis. Shows significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models. Provides cardioprotection by decreasing myocardial infarct size. Shows protective effects in models of stroke. Suppresses cell growth in liver cancer cells.

Small Business Enterprise

Catalog Number: (103228-838)
Supplier: Novus Biologicals
Description: LKB1/STK11 [p ser428] Antibody, Polyclonal, Host: Rabbit, Species: Human, Isotype: IgG, Immunogen: Phosphopeptide containing human LKB1/STK11 S428, Synonyms: EC 2.7.11.1, PJS polarization-related protein LKB1, PJS, Application: WB, Size: 100UG


Catalog Number: (103444-204)
Supplier: Affymetrix, Inc.
Description: Despite the predicted molecular weight, LKB1 often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is PC-3 cell lysate. PA5-20325 can be used with blocking peptide PEP-0445. The LKB1 serine/threonine protein kinase was initially identified as a tumor suppressor gene mutated in human Peutz-Jeghers syndrome (PJS), a condition resulting in the growth of numerous intestinal polyps classed as hamartomas. LKB1 exists as a heterotrimeric complex with two other proteins, Ste20-related adaptor protein (STRAD) and MO25. Together, this complex can phsophorylate and activate the AMP-activate protein kinase (AMPK). Following AMPK activation by LKB1, AMPK then phosphorylates TSC1 and TSC2, key components of the metabolism-regulating TOR signaling pathway, which antagonizes the activation for the TOR pathway. LKB1 has also been shown to play a fundamental role in controlling the spatial orientation of structures required to maintain an ordered, polarized epithelium.

Blocked

Supplier: MilliporeSigma
Description: Glutardialdehyde is a fixing agent for specimens destined for morphological and enzyme histochemical analysis of samples of human origin.

SDS

Catalog Number: (75929-652)
Supplier: Rockland Immunochemical
Description: The LKB1 serine/threonine protein kinase was initially identified as a tumor suppressor gene mutated in human Peutz-Jeghers syndrome (PJS), a condition resulting in the growth of numerous intestinal polyps classed as hamartomas. LKB1 exists as a heterotrimeric complex with two other proteins, Ste20-related adaptor protein (STRAD) and MO25. Together, this complex can phsophorylate and activate the AMP-activate protein kinase (AMPK). Following AMPK activation by LKB1, AMPK then phosphorylates TSC1 and TSC2, key components of the metabolism-regulating TOR signaling pathway, which antagonizes the activation for the TOR pathway. LKB1 has also been shown to play a fundamental role in controlling the spatial orientation of structures required to maintain an ordered, polarized epithelium.


Catalog Number: (103482-346)
Supplier: Affymetrix, Inc.
Description: A suggested positive control for this product is lung or uterus lysate. Germline mutations of the LKB1 (STK11) tumor suppressor gene can lead to Peutz-Jeghers syndrome (PJS) and a marked predisposition to cancer. LKB1 encodes a serine/threonine kinase that is inactivated in PJS. The tumor suppressor protein PTEN is a LKB1-interacting protein. Several point mutations in LKB1 are associated with PJS and may disrupt the interaction with PTEN suggesting that the loss of this interaction might contribute to PJS. PTEN and LKB1 are predominantly cytoplasmic and nuclear, respectively, the interaction of the two leads to a cytoplasmic relocalization of LKB1. PTEN is a substrate of the kinase LKB1 invitro.

Blocked

Supplier: Ambeed
Description: 3,4-Dimethoxybenzimidamide hydrochloride, Purity: 98%, CAS Number: 51488-33-6, Appearance: White to off white solid, Storage: Sealed in dry, Room Temperature, Size: 1g

Catalog Number: (103228-840)
Supplier: Novus Biologicals
Description: LKB1/STK11 [p ser428] Antibody, Polyclonal, Host: Rabbit, Species: Human, Isotype: IgG, Immunogen: Phosphopeptide containing human LKB1/STK11 S428, Synonyms: EC 2.7.11.1, PJS polarization-related protein LKB1, PJS, Application: WB, Size: 25UG


Catalog Number: (77749-413)
Supplier: Ambeed
Description: 3,4-Dimethoxyaniline hydrochloride 95+%

New Product


Supplier: Matrix Scientific
Description: 3,4-Dichloropyridine hydrochloride ≥98%

Supplier: Matrix Scientific
Description: MF=C9H12Clno2 MW=201.65 Cas=1653-64-1 MDL=MFCD00035193 ,5G

Supplier: Ambeed
Description: (R)-1-(3,4-Dimethoxyphenyl)ethanamine hydrochloride, Purity: 95%, CAS Number: 390815-41-5, Appearance: Solid, Storage: Inert atmosphere, 2-8 deg C, Size: 250mg

Supplier: Ambeed
Description: Pyridine-3,4-diyldimethanol hydrochloride, Purity: 98%, CAS Number: 53654-42-5, Appearance: White to Yellow Solid, Storage: Inert atmosphere, 2-8 deg C, Size: 5g

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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