You Searched For: GDC-0853


59  results were found

SearchResultCount:"59"

Sort Results

List View Easy View

Rate These Search Results

Supplier: Ambeed
Description: (S)-2-(3'-(Hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4'-bipyridin]-2'-yl)-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, Purity: 98+%, CAS Number: 1434048-34-6, Appearance: Solid, Size: 1mg

Catalog Number: (103444-986)
Supplier: Affymetrix, Inc.
Description: A suggested positive control is Raji cell lysate. PA5-20739 can be used with blocking peptide PEP-0853. RUNX1 is one of three mammalian RUNX genes that control multiple aspects of embryonic development and are responsible for the pathogenesis of many human diseases. RUNX1 plays major roles in the development of nociceptive sensory neurons in addition to hematopoietic stem cells (HSC) with the exception of the erythroid lineage. During development, Notch signals mediate RUNX1 induction with SCL/GATA/Ets factors, and Wnt signals potentially cooperate with RUNX1 to facilitate adult HSC expansion via cooperative induction of cyclin D, cdk4, and other cell cycle regulators. In turn, RUNX1 regulates cell cycle transitions dependent on functional/physical interactions with other proteins such as HDAC1 and -3, mSin3A, p300, SMAD proteins, and LEF/TCF.

Blocked

Catalog Number: (103334-618)
Supplier: Novus Biologicals
Description: The GDC Antibody (1H7) from Novus Biologicals is a mouse monoclonal antibody to GDC. This antibody reacts with human. The GDC Antibody (1H7) has been validated for the following applications: Western Blot, ELISA.


Supplier: Ambeed
Description: GDC-0349 ≥98%

New Product

Supplier: Adipogen
Description: GDC-0941 is a potent class I PI3 kinase (PI3K) inhibitor. It selectively binds to PI3K isoforms in an ATP-competitive manner. It has an IC(50) of 3nM, and shows slight selectivity toward p110beta (11-fold) and p110gamma (25-fold).

Catalog Number: (AAJ67082-LB0)
Supplier: Thermo Scientific Chemicals
Description: GDC-0068, 98%

Supplier: Adipogen
Description: GDC-0032 is a potent, next-generation beta isoform-sparing PI3K inhibitor targeting PI3Kalpha/delta/gamma with Ki of 0.29nM/0.12nM/0.97nM, <gt/>10 fold selective over PI3Kbeta.

Supplier: Ambeed
Description: GDC-0449 98%

New Product

Supplier: ALADDIN SCIENTIFIC CORPORATION
Description: ABT-199 (GDC-0199) is a BH3 mimetic that Bcl-2-selective inhibitor with Ki of <0.01 nM. B-cell lymphoma/leukemia 2 (Bcl-2) is an anti-apoptotic protein that controls cell survival by binding the BH3 domains of pro-death BAD and BAK proteins and preventing permeabilization of the mitochondrial outer membrane. This protein is tightly regulated for the homeostasis between cell growth and cell death.A Bcl-2-selective inhibitor with Ki of <0.01 nM

New Product

Supplier: Adipogen
Description: GDC046 is a potent selective TYK2 inhibitor (Ki=4.8nm) versus JAK1 (Ki=84nm) and JAK2 (Ki=28nm). It is a lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile.

Supplier: Ambeed
Description: GDC-0623 99+%

Supplier: Enzo Life Sciences
Description: Cell-permeable, potent inhibitor of PI3 kinase IA and IB

Supplier: Ambeed
Description: 5-(6,6-Dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl)pyrimidin-2-amine, Purity: 95%, CAS Number: 1382979-44-3, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20 C, Size: 25mg

Supplier: Ambeed
Description: GDC-0941 98+%

Supplier: Enzo Life Sciences
Description: Vismodegib is a potent, novel and specific inhibitor of hedgehog with IC50 of 3 nM and also inhibitor of P-gp with IC50 of 3.0 μM.

Catalog Number: (102192-864)
Supplier: Novus Biologicals
Description: The GDC Antibody from Novus Biologicals is a rabbit polyclonal antibody to GDC. This antibody reacts with human. The GDC Antibody has been validated for the following applications: Western Blot.


Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
1 - 16 of 59
no targeter for Bottom