You Searched For: Topotecan+hydrochloride

Supplier: Ambeed

Description: Topotecan hydrochloride 98%

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Supplier: Enzo Life Sciences

Description: Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin. Used in chemotherapy of several different cancers.

Catalog Number: (77671-058)

Supplier: Ambeed

Description: Topotecan ≥98%

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Catalog Number: (80055-528)

Supplier: MilliporeSigma

Description: Trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by camptothecin (80055-998) and topotecan in HL-60 cells. Heavy metals: <=10ppm.

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Catalog Number: (89367-424)

Supplier: Genetex

Description: MRP4 transports cyclic nucleotides and anti-retroviral compounds and may be an organic anion pump relevant to cellular detoxification. It is widely expressed, with particularly high levels in prostate, but is barely detectable in liver. It belongs to the ATP binding cassette (ABC) transporter family. MRP4 confers resistance to topotecan and acts as a double agent in protecting the brain from chemotherapy.

Catalog Number: (77437-636)

Supplier: Bioss

Description: An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.

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Catalog Number: (77436-882)

Supplier: Bioss

Description: An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.

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Supplier: TLC Standards

Description: Pharmaceutical Standards, Topotecan

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Supplier: TLC Standards

Description: Pharmaceutical Standards, (R)-Topotecan

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Supplier: TLC Standards

Description: Pharmaceutical Standards, Topotecan-d6 DiHCl

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Catalog Number: (77695-238)

Supplier: LGC STANDARDS

Description: Topotecan-d6, TRC, LGC Standards

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Supplier: Affymetrix, Inc.

Description: 5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. - test size: has been pre-titrated and tested by flow cytometric analysis of ABCG2 transfected cells and peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser ABCG2, is also known as placenta-specific ABC transporter and breast cancer resistance protein (BCRP1). ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Under normal conditions, ABCG2 may serve a protective function by removing toxins from the cell, and plays an important role in regulating stem cell differentiation. ABCG2 is responsible for the side population (SP) phenotype and is widely expressed in a large variety of stem cells, making it an important stem cell marker. ABCG2 may have N-linked glycosylation and may dimerize in vivo. ABCG2 is abundantly expressed in placenta, liver, intestine and stem cells.

Catalog Number: (102045-076)

Supplier: Affymetrix, Inc.

Description: 5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. ABCG2, is also known as placenta-specific ABC transporter and breast cancer resistance protein (BCRP1). ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Under normal conditions, ABCG2 may serve a protective function by removing toxins from the cell, and plays an important role in regulating stem cell differentiation. ABCG2 is responsible for the side population (SP) phenotype and is widely expressed in a large variety of stem cells, making it an important stem cell marker. ABCG2 may have N-linked glycosylation and may dimerize in vivo. ABCG2 is abundantly expressed in placenta, liver, intestine and stem cells.

Catalog Number: (10118-204)

Supplier: VWR

Description: L-Ornithine hydrochloride grade: reagent CAS Number: 3184-13-2 synonym(s): (S)?-?(+)?-?2, 5-?Diaminopentanoic Acid Hydrochloride, (S)?-?2, 5-?Diaminopentanoic Acid Monohydrochloride, L-Ornithine Monohydrochloride 500g

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Supplier: AVANTOR PERFORMANCE MATERIALS US

Description: L-Arginine Hydrochloride, Multi-Compendial

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Supplier: AVANTOR PERFORMANCE MATERIALS US

Description: Guanidine Hydrochloride, GenAR®

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