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Image Unavailable-10800-290

Anti-AXIN2 Rabbit Polyclonal Antibody

Catalog Number: (10800-290)
Supplier: Rockland Immunochemical
Description: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Image Unavailable-77307-344

Iridium(III) chloride hydrate 98%

Supplier: Ambeed
Description: Iridium(III) chloride hydrate 98%

Product Image-10751-216

Anti-AXIN2 Rabbit Polyclonal Antibody

Catalog Number: (10751-216)
Supplier: Prosci
Description: AXIN2 Antibody: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Image Unavailable-BT136495-5G

Iridium(III) chloride, anhydrous

Supplier: BeanTown Chemical
Description: CAS: 10025-83-9; EC No: 233-044-6; MDL No: MFCD00011063 UN No: UN3260; Haz Class: 8; Packing Group: II Powder; Molecular Formula: IrCl3; MW: 298.56 Melting Point: 763° Hygroscopic

SDS

Product Image-89495-458

VWR® Cleanroom Sponges

Supplier: VWR International
Description: A range of sponges, made with cleanroom materials, are designed for cleaning small parts, equipment, and other items in production or the lab.

Certificates Small Business Enterprise

Image Unavailable-10246-538

Anti-BEST2 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10246-538)
Supplier: Bioss
Description: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.
Product Image-100360-376

Iridium ICP Standard, Inorganic Ventures

Catalog Number: (100360-376)
Supplier: Inorganic Ventures
Description: Certified reference material for Iridium, traceable to NIST.
Image Unavailable-75969-092

Anti-TP53 Mouse Monoclonal Antibody (Biotin) [clone: BP53-12 DO-7]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Image Unavailable-75967-608

Anti-TP53 Mouse Monoclonal Antibody [clone: BP53-12 DO-7]

Catalog Number: (75967-608)
Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Image Unavailable-89050-400

Polysorbate 80 NF

Supplier: Spectrum Chemicals
Description: Polysorbate 80, NF is used to solubilize essential oils.

Certificates

Image Unavailable-TCT3716-200MG

Tris(2-phenylpyridinato)iridium(III) ≥98.0% (by HPLC)

Supplier: TCI America
Description: Tris(2-phenylpyridinato)iridium(III) ≥98.0% (by HPLC)

New Product

Image Unavailable-10262-362

Anti-DDX20 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10262-362)
Supplier: Bioss
Description: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord. SMA is caused by deletion or loss-of-function mutations in the SMN (survival of motor neuron) gene. Gemin3, also known as DP103, DDX20, DEAD-box protein DP130 and DEAD/H box 20, is a protein product of human chromosome 1p13.2. It associates directly with SMN and is a part of the SMN complex containing Gemin2, Gemin4, Gemin5 and Gemin6, as well as several spliceosomal snRNP proteins. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus. It is found in both the cytoplasm and the nucleus. The nuclear form is concentrated in subnuclear bodies called gems (for Gemini of the coiled bodies). Gemin3 also interacts with SmB, SmD2 and SmD3. It contains the conserved motif Asp-Glu-Ala-Asp (DEAD) characteristic of DEAD-box proteins. Gemin3 is a putative RNA helicase and shows ATPase activity. It is expressed in B and T cell neuroblastoma-derived cell lines, malignant melanoma tumor, normal testis and is expressed in low levels in colon, skeletal muscle, liver, kidney and lung.
Image Unavailable-BT138700-5G

Iridium(IV) oxide ≥99% (trace metals basis)

Supplier: BeanTown Chemical
Description: CAS: 12030-49-8; EC No: 234-743-9; MDL No: MFCD00011065 UN No: UN1479; Haz Class: 5.1; Packing Group: II Powder; Molecular Formula: IrO2; MW: 224.21

SDS

Image Unavailable-100207-170

Iridium(IV) oxide ≥99% (99.9+%-Ir)

Supplier: Strem Chemicals Inc
Description: CAS #: 12030-49-8. Size: 1g.

Image Unavailable-100205-200

(1,5-Cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate ≥99%

Supplier: Strem Chemicals Inc
Description: (Tricyclohexylphosphine)(1,5-cyclooctadiene)(pyridine)iridium (I) hexafluorophosphate,purity: Min 99%, CAS number: 64536-78-3, M F: C31H50F6IrNP2, Color: orange, Form: crystalline, Size: 0.25g

Image Unavailable-100210-082

Carbonylchlorobis(triphenylphosphine)iridium(I) ≥99%

Supplier: Strem Chemicals Inc
Description: CAS #: 14871-41-1. Size: 1g.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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