You Searched For: PF-4618433


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Supplier: Adipogen
Description: Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.

Supplier: VWR International
Description: Ambidextrous gloves are soft and comfortable for everyday use. They protect hands from a broad range of chemicals. Beaded cuff allows easy donning.
Supplier: VWR International
Description: These gloves are ambidextrous with textured fingers and a rolled, beaded cuff
Supplier: Ambeed
Description: Pf-06282999 98+%

New Product

Supplier: Adipogen
Description: Antagonizing the Chk1-mediated cell cycle checkpoints has emerged as an attractive target for anticancer therapy. If Chk1 activity is blocked, DNA-damaged or spindle-disrupted cells would exit cell cycle arrest before full repair and subsequently undergo mitotic catastrophe or cell death. Chk1 inhibitors consequently increase the therapeutic index of DNA-damaging or antimitotic agents as well. PF-0477736 is a selective, potent ATP-competitive Chk1 inhibitor, derived from PF-0394691, inhibits Chk1 (Ki, 0.49nM) and Chk2 (Ki, 47nM) in vitro. In tests, PF-0477736 was identified as a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49nM. PF-0477736 abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin. In xenografts, PF-0477736 enhanced the antitumor activity of gemcitabine in a dose-dependent manner. PF-0477736 combinations were well tolerated with no exacerbation of side effects commonly associated with cytotoxic agents.

Supplier: Adipogen
Description: PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kalpha (Ki= 0.13nM human, 0.299nM mouse) and PI3Kgamma (Ki=0.111nM), and PI3Kdelta (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.

Supplier: VWR International
Description: Ambidextrous 6 mil gloves are extra-soft and comfortable for everyday use. They protect hands from a broad range of chemicals.
Catalog Number: (89161-702)
Supplier: Enzo Life Sciences
Description: Specific non-chelating small-molecule inhibitor of MMP-12 (IC50 = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function.


Supplier: VWR International
Description: Advanced nitrile material formulation features added thickness to provide excellent barrier protection. Gloves are produced in ISO certified facilities.
Supplier: VWR International
Description: Blue light nitrile examination gloves offer a thin 2 mil finger thickness that provides protection against a broad range of chemicals. These gloves are made of premium compounded nitrile for high manufacturing quality measures and product consistency.

Supplier: Ambeed
Description: PF-9366 98%

New Product

Supplier: Ambeed
Description: PF-562271 besylate 98%

Supplier: Ambeed
Description: PF-06840003 98%

Supplier: Ambeed
Description: PF-05212384 ≥98%

Supplier: Adipogen
Description: Antibiotic PF 1052 is antifungal and phytotoxic.

Small Business Enterprise

Supplier: Ambeed
Description: PF-04708671 98%

New Product

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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