You Searched For: GDC-0623

Supplier: Ambeed

Description: GDC-0623 99+%

Catalog Number: (103444-550)

Supplier: Affymetrix, Inc.

Description: A suggested positive control is human brain tissue lysate. PA5-20503 can be used with blocking peptide PEP-0623. Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.

Catalog Number: (VF-HFO-SE)

Supplier: Speakman

Description: This combined safety device can be used to flush contaminants from eyes, face, or entire body.

Catalog Number: (102469-678)

Supplier: Affymetrix, Inc.

Description: 5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. eFluor®® 660 is a replacement for Alexa Fluor® 647. eFluor®® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1).

Supplier: Ambeed

Description: GDC-0349 ≥98%

New Product

Catalog Number: (103334-618)

Supplier: Novus Biologicals

Description: The GDC Antibody (1H7) from Novus Biologicals is a mouse monoclonal antibody to GDC. This antibody reacts with human. The GDC Antibody (1H7) has been validated for the following applications: Western Blot, ELISA.

Catalog Number: (AAJ67082-LB0)

Supplier: Thermo Scientific Chemicals

Description: GDC-0068, 98%

SDS Certificates

Supplier: Adipogen

Description: GDC-0032 is a potent, next-generation beta isoform-sparing PI3K inhibitor targeting PI3Kalpha/delta/gamma with Ki of 0.29nM/0.12nM/0.97nM, <gt/>10 fold selective over PI3Kbeta.

Supplier: Ambeed

Description: GDC-0449 98%

New Product

Supplier: Adipogen

Description: GDC046 is a potent selective TYK2 inhibitor (Ki=4.8nm) versus JAK1 (Ki=84nm) and JAK2 (Ki=28nm). It is a lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile.

Supplier: Enzo Life Sciences

Description: Cell-permeable, potent inhibitor of PI3 kinase IA and IB

Supplier: Ambeed

Description: GDC-0941 98+%

Supplier: Adipogen

Description: GDC-0941 is a potent class I PI3 kinase (PI3K) inhibitor. It selectively binds to PI3K isoforms in an ATP-competitive manner. It has an IC(50) of 3nM, and shows slight selectivity toward p110beta (11-fold) and p110gamma (25-fold).

Supplier: Enzo Life Sciences

Description: Vismodegib is a potent, novel and specific inhibitor of hedgehog with IC50 of 3 nM and also inhibitor of P-gp with IC50 of 3.0 μM.

Supplier: Ambeed

Description: 2-(4-(2-(1-Isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, Purity: 98+%, CAS Number: 1282512-48-4, Appearance: White to Yellow Solid, Storage: Sealed in dry, 2-8 deg C, Size: 5mg

Supplier: Ambeed

Description: (S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide, Purity: 98+%, CAS Number: 873652-48-3, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20 C, Size: 1mg