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Catalog Number: (AAJ67082-LB0)
Supplier: Thermo Scientific Chemicals
Description: GDC-0068, 98%

Supplier: Ambeed
Description: (S)-2-(4-Chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one, Purity: 98%, CAS Number: 1001264-89-6, Appearance: Solid, Storage: Keep in dark place, Sealed in dry, Store in freezer, under -20 C, Size: 10mg

Supplier: Chemglass
Description: Unions are made from 316 stainless steel.

Small Business Enterprise

Catalog Number: (103443-560)
Supplier: Affymetrix, Inc.
Description: In Western blot applications, this antibody detects a band at ~32kDa. A suggested positive control is A549 cell lysate. PA5-19943 can be used with blocking peptide PEP-0068. Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. Several molecules including caspases and adaptor FADD contain DEDs. A novel protein that interacts with DED of caspase-8 and 10, and FADD was identified recently and designated DEDAF for DED associated factor. DEDAF is identical to the transcriptional repressor RYBP. DEDAF/RYBP is expressed in multiple tissues and cell lines. DEDAF interacts with FADD and augments the formation of CD95/FADD/capase-8 complexes at the cell membrane, and interacts with DED-containing DNA biding protein (DEDD) in the nucleus indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.

Blocked

Supplier: Adipogen
Description: GDC-0941 is a potent class I PI3 kinase (PI3K) inhibitor. It selectively binds to PI3K isoforms in an ATP-competitive manner. It has an IC(50) of 3nM, and shows slight selectivity toward p110beta (11-fold) and p110gamma (25-fold).

Supplier: Adipogen
Description: GDC-0032 is a potent, next-generation beta isoform-sparing PI3K inhibitor targeting PI3Kalpha/delta/gamma with Ki of 0.29nM/0.12nM/0.97nM, <gt/>10 fold selective over PI3Kbeta.

Catalog Number: (103334-618)
Supplier: Novus Biologicals
Description: The GDC Antibody (1H7) from Novus Biologicals is a mouse monoclonal antibody to GDC. This antibody reacts with human. The GDC Antibody (1H7) has been validated for the following applications: Western Blot, ELISA.


Supplier: Enzo Life Sciences
Description: Cell-permeable, potent inhibitor of PI3 kinase IA and IB

Supplier: Ambeed
Description: GDC-0349 ≥98%

New Product

Supplier: Ambeed
Description: 5-(6,6-Dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl)pyrimidin-2-amine, Purity: 95%, CAS Number: 1382979-44-3, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20 C, Size: 25mg

Supplier: Ambeed
Description: GDC-0449 98%

New Product

Supplier: Ambeed
Description: GDC-0623 99+%

Supplier: Adipogen
Description: GDC046 is a potent selective TYK2 inhibitor (Ki=4.8nm) versus JAK1 (Ki=84nm) and JAK2 (Ki=28nm). It is a lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile.

Supplier: Ambeed
Description: 2-(4-(2-(1-Isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, Purity: 98+%, CAS Number: 1282512-48-4, Appearance: White to Yellow Solid, Storage: Sealed in dry, 2-8 deg C, Size: 5mg

Supplier: Ambeed
Description: GDC-0941 98+%

Supplier: ALADDIN SCIENTIFIC CORPORATION
Description: ABT-199 (GDC-0199) is a BH3 mimetic that Bcl-2-selective inhibitor with Ki of <0.01 nM. B-cell lymphoma/leukemia 2 (Bcl-2) is an anti-apoptotic protein that controls cell survival by binding the BH3 domains of pro-death BAD and BAK proteins and preventing permeabilization of the mitochondrial outer membrane. This protein is tightly regulated for the homeostasis between cell growth and cell death.A Bcl-2-selective inhibitor with Ki of <0.01 nM

New Product

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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