You Searched For: (R)-1-(2-Chlorophenyl)ethanol

Supplier: Matrix Scientific

Description: Matrix Scientific Part Number: 044094-5G , MDL Number: MFCD00172032

Supplier: Ambeed

Description: Lumefantrine 98%

Supplier: Thermo Scientific Chemicals

Description: beta-2-adrenergic receptor agonist

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Catalog Number: (102544-354)

Supplier: Matrix Scientific

Description: MF=C30H32CL3NO MW=528.95 CAS=82186-77-4 MDL=MFCD05662268 1G

Catalog Number: (TCC1361-025G)

Supplier: TCI America

Description: CAS Number: 13524-04-4
MDL Number: MFCD00041037
Molecular Formula: C8H9ClO
Molecular Weight: 156.61
Purity/Analysis Method: >97.0% (GC)
Form: Clear Liquid
Boiling point (°C): 116
Flash Point (°C): 110
Specific Gravity (20/20): 1.18

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Supplier: TCI America

Description: CAS Number: 3391-10-4
MDL Number: MFCD00041038
Molecular Formula: C8H9ClO
Molecular Weight: 156.61
Purity/Analysis Method: >97.0% (GC)
Form: Clear Liquid
Boiling point (°C): 136
Flash Point (°C): 113
Specific Gravity (20/20): 1.17

SDS

Catalog Number: (TCB0490-025G)

Supplier: TCI America

Description: CAS Number: 92-00-2
MDL Number: MFCD00002852
Molecular Formula: C10H14ClNO2
Molecular Weight: 215.68
Purity/Analysis Method: >90.0% (GC)
Form: Crystal
Melting point (°C): 84

SDS

Supplier: Ambeed

Description: NG52 ≥98%

New Product

Supplier: Ambeed

Description: (R)-4-Chloro-alpha-methylbenzyl Alcohol, Purity: 95%, CAS Number: 75968-40-0, Appearance: Solid or liquid, Storage: Sealed in dry, 2-8 deg C, Size: 250mg

Supplier: Adipogen

Description: PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with an IC(50) of 31nM.

Supplier: Adipogen

Description: CX-4945 is a first-in-class, orally active, potent and selective inhibitor of the protein kinase CK2, with an IC(50) of 1nM.

Catalog Number: (IC19136105)

Supplier: MP Biomedicals

Description: An antiseptic and disinfectant agent. It is effective against a wide range of bacteria, some fungi and some viruses, and an agent for the prevention of gingivitis. Commercial ophthalmic products have used this agent to replace thimerosal as a preservative; however, it can cause skin irritation.

Supplier: Adipogen

Description: (+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor (IC(50) values of 17.7, 32.6, 76.9 and 12942nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP, respectively. In binding assays, (+)-JQ1 binds competitive with acetyl lysine to BRD4 bromodomain 1 (Kd=50nM) and and BRD4 bromodomain 2 (Kd=90 nM). May be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. (+)-JQ1 exhibited strong dose- and time-dependent inhibition of BRDT, a bromodomain-containing protein highly enriched in testis. BRDT is involved in chromatin remodeling and is essential for healthy sperm development. (+)-JQ1 appears to block that function and causes a decrease in sperm viability, being examined as a potential male contraceptive. Inhibitor of inflammation and bone destruction.

Supplier: Adipogen

Description: Selumetinib (AZD6244) is a second-generation, orally available, potent and selective ATP non-competitive inhibitor of MEK 1/2. In direct assays, AZD6244 selectively inhibits purified active MEK1 and MEK2 with an IC(50) of 14nM, and AZD6244 has reported IC(50) values of <lt/>100nm for MEK1 in ELISA assays and in bindings assays against recombinant domains of MEK2, Kd values were 53nM for AZD6244. AZD6244 demonstrated very effective anti-proliferation effects against several different cell lines with IC(50) values ranging from a low of 3nM to <lt/> 1µM depending upon the cell system used, and the compound inhibits basal and growth factor-stimulated phosphorylation of ERK1/ 2 with IC(50) concentrations <lt/> 40nM. AZD6244 has demonstrated potent dose-dependent antitumor activity against a panel of mouse xenograft models of colorectal, pancreatic, liver, skin, and lung cancer, and inhibition of tumor growth was found to correlate with the reduction of phospho-ERK1/2 levels in tumors.

Supplier: Adipogen

Description: Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. The role of Aurora C is unclear; however, Aurora C can complement Aurora B kinase activity in mitosis. SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. A cocrystal structure of SNS-314 with Aurora A confirms that SNS-314 engages the purine-binding pocket of Aurora. SNS-314 inhibits cellular proliferation in the HCT116 colorectal carcinoma cell line with an EC50 of ~5nM. Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. Administration of SNS-314 to HCT116 tumor bearing mice potently suppresses tumor growth. Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent.

Supplier: VWR International

Description: Ethanol denatured ACS (denatured with 5% isopropanol and 5% methanol), VWR Chemicals BDH®

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