You Searched For: Phorbol-12-myristate-13-acetate

Supplier: MP Biomedicals

Description: PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA’s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC.
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Potent tumor promoter; activates protein kinase C in vivo and in vitro.
Store at -20 °C. Protect from light.

Supplier: Thermo Scientific Chemicals

Description: Phorbol-12-myristate-13-acetate 97%

Supplier: Enzo Life Sciences

Description: PKC activator

Supplier: MilliporeSigma

Description: Most commonly-used phorbol ester

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Supplier: Ambeed

Description: Phorbol-12-myristate-13-acetate 95%

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Supplier: Thermo Scientific Chemicals

Description: Activates protein kinase C and promotes skin tumors in mice.

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Supplier: Adipogen

Description: Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin.