Phorbol 12-myristate 13-acetate ≥98% (by HPLC)

Supplier: ADIPOGEN CORP MS
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Synonyms: TPA, Phorbol 12-myristate 13-acetate, 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-Acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate

AG-CN2-0010-M001 AG-CN2-0010-M005 AG-CN2-0010-M010 AG-CN2-0010-M025
102515-692EA 48.46 USD
102515-692 102515-694 102515-696 102515-698
Phorbol 12-myristate 13-acetate ≥98% (by HPLC)
Phorbol-12-myristate-13-acetate

Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin.

Formula: C₃₆H₅₆O₈
MW: 616.836 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00036736
CAS Number: 16561-29-8

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Specification Test Results

Source/Host Semisynthetic.
Purity 98% (HPLC)
Appearance/Color White to off-white solid.
Solubility Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers.

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