Phorbol-12-myristate-13-acetate ≥99%, colorless material
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
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Warning
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Synonyms:
TPA, Phorbol 12-myristate 13-acetate, 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-Acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA’s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC.
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Potent tumor promoter; activates protein kinase C in vivo and in vitro.
Store at -20 °C. Protect from light.
- Purity: >99%
- Presentation: Colorless Material
- Very soluble in methanol; soluble in DMSO (25 mg/mL), chloroform (25 mg/mL), ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Formula:
C₃₆H₅₆O₈ MW: 616.836 g/mol Melting Pt: 50…70 °C (lit.) Storage Temperature: Freezer |
MDL Number:
MFCD00036736 CAS Number: 16561-29-8 |
Specification Test Results
Identity Test | Passes |
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