You Searched For: Src+inhibitor-1

Catalog Number: (89158-280)

Supplier: Enzo Life Sciences

Description: Potent, dual site (ATP domain and substrate-binding domain) Src and Lck kinase inhibitor (IC50=44 and 88nM respectively). VEGFR2 IC50=0.32μM; c-fms IC50=30μM.

Supplier: Ambeed

Description: 6,7-Dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine, Purity: 99%, CAS Number: 179248-59-0, Appearance: White to yellow or pale-pink powder or crystals, Storage: Sealed in dry, 2-8 C, Size: 10mg

Catalog Number: (89161-196)

Supplier: Enzo Life Sciences

Description: Src kinase inhibitor

Catalog Number: (89147-868)

Supplier: Enzo Life Sciences

Description: Src kinase inhibitor

Catalog Number: (89161-206)

Supplier: Enzo Life Sciences

Description: Src kinase inhibitor

Supplier: Enzo Life Sciences

Description: Src kinase inhibitor

Supplier: Enzo Life Sciences

Description: Src kinase inhibitor

Catalog Number: (89161-210)

Supplier: Enzo Life Sciences

Description: Src kinase substrate

Supplier: Adipogen

Description: PD173955-Analog1 is a potent c-Src inhibitor with an IC(50) value of 9nM. It is also a weaker inhibitor of PDGFR, FGFR and EGFR with IC(50) values of 130nM, 110nM and 190nM respectively.

Supplier: Enzo Life Sciences

Description: Potent and orally active Lck/Src inhibitor.

Supplier: ALADDIN SCIENTIFIC CORPORATION

Description: AD80, a multi kinase inhibitor, has strong activity on human RET (c-RET), BRAF, S6K and SRC, but weak activity on mTOR than ad57 or ad58. Its IC50 value for RET (c-RET) is 4 nm.

New Product

Supplier: Adipogen

Description: PD173955 is an ATP-competitive, dual Src/Bcr-Abl kinase inhibitor. It is a potent inhibitor of Bcr-Abl with an IC(50) of 1-2nM in kinase inhibition assays. In cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 also inhibits Src kinase activity in vitro with an IC(50) of 22nM and could represent a novel class of anti-mitotic drug.

Supplier: Adipogen

Description: CGI1746 was identified as a selective and potent ATP-competitive BTK inhibitor with an IC(50) of 1.9nM. It is specific for BTK, with around 1000-fold selectivity over Tec and Src family kinases.

Supplier: Adipogen

Description: CP-724714 is an oral, selective and potent ErbB-2 (HER2) kinase inhibitor with an IC(50) of 10 nM. It has <gt/>640-fold selectivity for ErbB-2 (HER2) over EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met.

Supplier: Enzo Life Sciences

Description: Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

Catalog Number: (10254-124)

Supplier: Bioss

Description: c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.