You Searched For: PF-477736


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Supplier: Adipogen
Description: Antagonizing the Chk1-mediated cell cycle checkpoints has emerged as an attractive target for anticancer therapy. If Chk1 activity is blocked, DNA-damaged or spindle-disrupted cells would exit cell cycle arrest before full repair and subsequently undergo mitotic catastrophe or cell death. Chk1 inhibitors consequently increase the therapeutic index of DNA-damaging or antimitotic agents as well. PF-0477736 is a selective, potent ATP-competitive Chk1 inhibitor, derived from PF-0394691, inhibits Chk1 (Ki, 0.49nM) and Chk2 (Ki, 47nM) in vitro. In tests, PF-0477736 was identified as a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49nM. PF-0477736 abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin. In xenografts, PF-0477736 enhanced the antitumor activity of gemcitabine in a dose-dependent manner. PF-0477736 combinations were well tolerated with no exacerbation of side effects commonly associated with cytotoxic agents.

Supplier: VWR International
Description: Ambidextrous gloves are soft and comfortable for everyday use. They protect hands from a broad range of chemicals. Beaded cuff allows easy donning.
Supplier: VWR International
Description: These gloves are ambidextrous with textured fingers and a rolled, beaded cuff
Supplier: VWR International
Description: Ambidextrous 6 mil gloves are extra-soft and comfortable for everyday use. They protect hands from a broad range of chemicals.
Supplier: Ambeed
Description: PF-04708671 98%

New Product

Supplier: VWR International
Description: Advanced nitrile material formulation features added thickness to provide excellent barrier protection. Gloves are produced in ISO certified facilities.
Supplier: Adipogen
Description: PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays <gt/>100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections.

Catalog Number: (77746-927)
Supplier: Ambeed
Description: PF 543 HCl ≥97%

New Product


Supplier: VWR International
Description: Blue light nitrile examination gloves offer a thin 2 mil finger thickness that provides protection against a broad range of chemicals. These gloves are made of premium compounded nitrile for high manufacturing quality measures and product consistency.

Supplier: Ambeed
Description: PF-9366 98%

New Product

Supplier: Ambeed
Description: PF-06840003 98%

Supplier: Ambeed
Description: PF-05212384 ≥98%

Supplier: Ambeed
Description: Pf-06282999 98+%

New Product

Supplier: Ambeed
Description: PF-04554878 99%

New Product

Supplier: Adipogen
Description: Antibiotic PF 1052 is antifungal and phytotoxic.

Small Business Enterprise

Supplier: Adipogen
Description: Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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