PF-562271 ≥95%

Supplier: ADIPOGEN CORP MS
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Synonyms: N-Methyl-N-(3-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)methanesulphonamide

SYN-1064-M001 SYN-1064-M005 SYN-1064-M010 SYN-1064-M050
102991-752EA 119.08 USD
102991-752 102991-754 102991-756 102991-758
PF-562271 ≥95%
PF-562271

PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays 100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections.

Formula: C₂₁H₂₀F₃N₇O₃S
MW: 507.5 g/mol
Storage Temperature: Freezer
MDL Number: MFCD16038299
CAS Number: 717907-75-0

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Specification Test Results

Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO or ethanol.

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