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You Searched For: O-Methyl-L-tyrosine


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Product Image-101855-858

Boc-N-Me-Tyr(Bzl)-OH

Supplier: Matrix Scientific
Description: Matrix Scientific Part Number: 042451-1G , MDL Number: MFCD00038755

Image Unavailable-103008-080

HIV Tat-GluR23Y

Catalog Number: (103008-080)
Supplier: Anaspec Inc
Description: The synthetic peptide (Tat-Glur23Y) contains tyrosine residues that blocks phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. Previous research shows that Tat-Glur23Y blocks regulated AMPA and thereby prevents long-term depression (LTD) in structures such as the nucleus accumbens and dorsal hippocampus.
Sequence: YGRKKRRQRRRYKEGYNVYG
MW: 2634 Da
% Peak area by HPLC: 95
Storage condition: -20°C
Image Unavailable-76790-362

Z-Tyr(tBu)-OMe 98%

Supplier: Ambeed
Description: (S)-Methyl 2-(((benzyloxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoate, Purity: 98%, CAS Number: 5068-29-1, Appearance: Solid, Storage: Sealed in dry, Room Temperature, Size: 5G

Image Unavailable-102991-696

Nilotinib

Supplier: Adipogen
Description: Nilotinib is an orally bio-available aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor (IC(50) <lt/>30nM) with anti-neoplastic activity.

Image Unavailable-77157-170

z-Tyr-OMe 97%

Supplier: Ambeed
Description: Z-Tyr-OMe, Purity: 97%, CAS Number: 13512-31-7, Appearance: Form: powder Colour: white, Storage: Keep in dark place, Sealed in dry, Room Temperature, Size: 100g

Image Unavailable-102991-664

Masatinib ≥95%

Supplier: Adipogen
Description: Masitinib is a potent, orally available protein tyrosine kinase inhibitor targeting c-Kit, PDGFR and FGFR3. It demonstrates activity for Kit and PDGFRalpha/beta with IC(50) values of 200nM, 540nM and 800nM respectively. It shows weak inhibition of ABL and c-Fms.

Image Unavailable-89149-530

Galiellalactone (from unidentified fungus MST-FP1888) ≥95% (by HPLC)

Catalog Number: (89149-530)
Supplier: Enzo Life Sciences
Description: Originally isolated from Galiella rufa as a plant growth regulator. Inhibits IL-6 mediated signal transduction by blocking the binding of the activated STAT3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation site of the STAT3 transcription factor.
Image Unavailable-103008-078

HIV Tat-Glur23y, Scrambled

Catalog Number: (103008-078)
Supplier: Anaspec Inc
Description: Tat-Glur23Y, scrambled is a control peptide. The synthetic peptide (Tat-Glur23Y), containing tyrosine residues, blocks phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. However, the scrambled version does not have blockade properties. Previous studies show that Tat-Glur23Y, scrambled increase stress levels in mice, while Tat-Glur23Y reduces stress when administered.
Sequence: YGRKKRRQRRRVYKYGGYNE
MW: 2634 Da
% Peak area by HPLC: 95
Storage condition: -20°C
Image Unavailable-ALA126334-1MG

N-(4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine ≥98%

Supplier: ALADDIN SCIENTIFIC
Description: The product is the analog of ARRY-380, ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFRA potent, selective, small-molecule tyrosine kinase HER2 inhibitor

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Lapatinib ≥95%

Supplier: Adipogen
Description: Lapatinib is an ATP-competitive epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) dual tyrosine kinase inhibitor, with IC(50) values of 10.8 and 9.2nM respectively. It is an orally active drug for treatment of breast cancer and other solid tumors.

Image Unavailable-102991-592

GW-441756 ≥95%

Supplier: Adipogen
Description: GW441756 is an orally active, potent and highly selective TrkA tyrosine kinase inhibitor (IC(50) of 2nM). It specifically blocks TrkA-induced cell death in a dose-dependent manner.

Image Unavailable-89158-210

Midostaurin ≥98% (by TLC)

Supplier: Enzo Life Sciences
Description: Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.

Image Unavailable-102991-620

JNJ-38877605 ≥95%

Supplier: Adipogen
Description: JNJ38877605 is an orally bio-available, small-molecule, c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (c-MET enzyme and Phospho-MET IC(50) values of 4nM and 50nM, respectively) and highly specific (selective over 229 other kinases tested).

Product Image-101853-706

Boc-D-Tyr(ME)-OH ≥95%

Supplier: Matrix Scientific
Description: Matrix Scientific Part Number: 041913-5G , MDL Number: MFCD00065604

Image Unavailable-102992-268

JNJ-38158471 ≥95%

Supplier: Adipogen
Description: JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with an IC(50) of 40nM. It also inhibits closely related tyrosine kinases such as Ret (IC(50) of 180nM) and Kit (C50 of 500nM). It has no significant activity (<gt/>1µM) against VEGFR-1 and VEGFR-3.

Image Unavailable-10253-602

Anti-PTPN5 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10253-602)
Supplier: Bioss
Description: The brain-specific STEP (striatal enriched phosphatase) family of protein tyrosine phosphatases (PTPs) comprises both transmembrane and cytosolic protein members which are the products of alternative splicing. STEP family members are expressed in the dopaminoceptive neurons of the CNS, with highest expression in the basal ganglia and related structures. The STEP protein regulates the N-methyl-d-aspartate receptor (NMDAR) complex; STEP depresses both NMDAR single-channel activity and synaptic currents. The membrane-associated STEP61 isoform localizes in the postsynaptic densities (PSDs) of striatal neurons. STEP61 contains a single tyrosine phosphatase domain, two proline-rich domains and two transmembrane domains. The STEP61 protein associates with the Src family kinase member Fyn when Fyn is phosphorylated at Tyr-420 and not Tyr-431. Upon association, STEP61 dephosphorylates Tyr-420 residue and may thus regulate Fyn activity in PSDs. Isolated from mouse brain, the STEP20 isoform lacks the conserved tyrosine phosphatase domain. The human STEP gene maps to chromosome 11p15.2-p15.1.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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