You Searched For: GDC-0084


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Supplier: Ambeed
Description: 5-(6,6-Dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl)pyrimidin-2-amine, Purity: 95%, CAS Number: 1382979-44-3, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20 C, Size: 25mg

Catalog Number: (103443-586)
Supplier: Affymetrix, Inc.
Description: In Western blot applications, this antibody detects a band at ~65kDa. A suggested positive control is Hela cell lysate. PA5-19959 can be used with blocking peptide PEP-0084. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

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Catalog Number: (103334-618)
Supplier: Novus Biologicals
Description: The GDC Antibody (1H7) from Novus Biologicals is a mouse monoclonal antibody to GDC. This antibody reacts with human. The GDC Antibody (1H7) has been validated for the following applications: Western Blot, ELISA.


Supplier: Adipogen
Description: GDC-0941 is a potent class I PI3 kinase (PI3K) inhibitor. It selectively binds to PI3K isoforms in an ATP-competitive manner. It has an IC(50) of 3nM, and shows slight selectivity toward p110beta (11-fold) and p110gamma (25-fold).

Supplier: Adipogen
Description: GDC-0032 is a potent, next-generation beta isoform-sparing PI3K inhibitor targeting PI3Kalpha/delta/gamma with Ki of 0.29nM/0.12nM/0.97nM, <gt/>10 fold selective over PI3Kbeta.

Supplier: ALADDIN SCIENTIFIC CORPORATION
Description: ABT-199 (GDC-0199) is a BH3 mimetic that Bcl-2-selective inhibitor with Ki of <0.01 nM. B-cell lymphoma/leukemia 2 (Bcl-2) is an anti-apoptotic protein that controls cell survival by binding the BH3 domains of pro-death BAD and BAK proteins and preventing permeabilization of the mitochondrial outer membrane. This protein is tightly regulated for the homeostasis between cell growth and cell death.A Bcl-2-selective inhibitor with Ki of <0.01 nM

New Product

Supplier: Enzo Life Sciences
Description: Cell-permeable, potent inhibitor of PI3 kinase IA and IB

Supplier: Ambeed
Description: GDC-0623 99+%

Supplier: Ambeed
Description: GDC-0349 ≥98%

New Product

Catalog Number: (AAJ67082-LB0)
Supplier: Thermo Scientific Chemicals
Description: GDC-0068, 98%

Supplier: Ambeed
Description: GDC-0449 98%

New Product

Supplier: Ambeed
Description: GDC-0941 98+%

Supplier: Adipogen
Description: GDC046 is a potent selective TYK2 inhibitor (Ki=4.8nm) versus JAK1 (Ki=84nm) and JAK2 (Ki=28nm). It is a lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile.

Catalog Number: (102192-862)
Supplier: Novus Biologicals
Description: The GDC Antibody from Novus Biologicals is a rabbit polyclonal antibody to GDC. This antibody reacts with human. The GDC Antibody has been validated for the following applications: Western Blot.


Catalog Number: (102192-864)
Supplier: Novus Biologicals
Description: The GDC Antibody from Novus Biologicals is a rabbit polyclonal antibody to GDC. This antibody reacts with human. The GDC Antibody has been validated for the following applications: Western Blot.


Supplier: Ambeed
Description: 2-(4-(2-(1-Isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, Purity: 98+%, CAS Number: 1282512-48-4, Appearance: White to Yellow Solid, Storage: Sealed in dry, 2-8 deg C, Size: 5mg

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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