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Supplier: Biotium

Description: Human Nuclear Antigen, Monoclonal antibody, Clone: 235-1, Host: Mouse, Species reactivity: Human, Non-human primates, Isotype: IgG1, kappa, Conjugate: CF543, Immunogen: Nuclei of human myeloid leukemia biopsy cells, Synonyms: HNA; HuNu, Application: IF, Size: 500uL

Catalog Number: (75924-204)

Supplier: Biotium

Description: This monoclonal antibody is part of a new panel of reagents, which recognizes subcellular organelles or compartments of human cells. These markers may be useful in identification of these organelles in cells, tissues, and biochemical preparations. This MAb recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells. This MAb produces a homogeneous staining pattern in the nucleus of normal and malignant cells.,Deoxyribonucleic acid (DNA) is a long polymer of nucleotides that is held together by a backbone made of sugars and phosphate groups. It holds the genetic instructions for the development and function of living things. DNA is crucial for living organisms, and all known cellular life and some viruses contain DNA. In eukaryotes, DNA exists in the cell nucleus, while in prokaryotes; DNA is located in the cytoplasm. In living organisms, DNA does not usually exist as a single molecule, but instead as a tightly associated pair of molecules in the shape of a right-handed double helix. Hydrogen bonds as well as forces generated by the hydrophobic effect and pi stacking hold the two DNA strands together. During replication and transcription, portions of the helix unwind and become single stranded. Protective proteins surround these single-stranded DNA. Double stranded (ds) DNA markers are useful tools in biology research and aid in the study of DNA behavior and characteristics.

Supplier: Biotium

Description: Tyrosinase, Monoclonal antibody, Clone: T311, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF647, Immunogen: Recombinant tyrosinase protein (T311); Recombinant human TYR protein, Synonyms: CMM8, LB24-AB, Application: IF, Size: 100uL

Supplier: Biotium

Description: UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Supplier: Biotium

Description: UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

Supplier: Biotium

Description: Human Nuclear Antigen, Monoclonal antibody, Clone: NM106, Host: Mouse, Species reactivity: Human, Non-human primates, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Nuclei of human myeloid leukemia biopsy cells, Synonyms: HNA; HuNu, Application: IF, Size: 500uL

Supplier: Biotium

Description: Human Nuclear Antigen, Monoclonal antibody, Clone: NM106, Host: Mouse, Species reactivity: Human, Non-human primates, Isotype: IgG1, kappa, Conjugate: CF543, Immunogen: Nuclei of human myeloid leukemia biopsy cells, Synonyms: HNA; HuNu, Application: IF, Size: 100uL

Supplier: Biotium

Description: Von Willebrand Factor, Monoclonal antibody, Clone: 3E2D10, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant human vWF fragment spanning aa 845-949, Synonyms: Coagulation Factor VIII, Application: IF, Size: 100uL

Supplier: Biotium

Description: CD45RA Monoclonal antibody, Clone: PTPRC/1148, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Recom full-length human CD45RA protein, Synonyms: B220, CD45R, Application: IF, IHC, FC, Size: 100uL

Supplier: Biotium

Description: CD45RB Monoclonal antibody, Clone: BRA-11G, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Non-T, non-B CALLA positive ALL cell line REH, Synonyms: B220, CD45R, Application: IF, IHC, FC, Size: 500 uL

Supplier: Biotium

Description: Vimentin, Monoclonal antibody, Clone: VM1170, Host: Mouse, Species reactivity: Mouse, Pig, Cow, Cat, Sheep, Rat, Human, Rabbit, Isotype: IgM, Conjugate: CF647, Immunogen: Human thymic nuclear extract, Synonyms: VIM, Application: IF, Size: 500uL

Supplier: Biotium

Description: This MAb recognizes proteins of 19-22 kDa (reducing) and 38 kDa-44 kDa (non-reducing), identified as various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor (VEGF/VPF). It is highly specific to VEGF, which is a homodimeric, disulfide-linked glycoprotein with a close homology to platelet derived growth factor (PDGF). There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Supplier: Biotium

Description: VEGFR1 / Flt-1, Monoclonal antibody, Clone: FLT1/658, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant human VEGF-R1 protein, Application: Immunofluorescence, Flow cytometry, Size: 500uL

Supplier: Biotium

Description: VEGFR1 / Flt-1, Monoclonal antibody, Clone: FLT1/658, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recombinant human VEGF-R1 protein, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

Description: Von Willebrand Factor, Monoclonal antibody, Clone: 3E2D10 + VWF635, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recombinant human vWF fragment spanning aa 845-949, Synonyms: Coagulation Factor VIII, Size: 100uL

Supplier: Biotium

Description: This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- & Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.