Catalog Number:
(103462-266)
Clearance
Supplier:
Affymetrix, Inc.
Description:
MA1-24734 detects TGF beta 1 from human samples. MA1-24734 has been successfully used in inhibition assay, ELISA, and Western blot procedures. By ELISA, the antibody shows less than 5% cross-reactivity with TGF-beta 1.2 and less than 1% cross reactivity with TGF beta 2, TGF beta 3, and TGF beta 5. The MA1-24734 immunogen is recombinant, full length human protein expressed in CHO cells. Store at 4ºC short term. For long term storage, store at -20ºC, avoiding freeze/thaw cycles. Transforming Growth Factor Beta 1 is a multifunctional peptide capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed as well as non-neoplastic tissues, release transforming growth factors; and essentially all cells possess a specific TGF beta 1 receptor. The multi-modal nature of TGF beta 1 is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta 1 whereas hepatocytes, T and B lymphocytes, keratinocytes and many epithelial cells are inhibited by the peptide. TGF beta 1 interacts with Epidermal Growth Factor, Platelet Derived Growth Factor, Fibroblast Growth Factor, and IL2 either by enhancing or antagonizing their characteristic actions. TGF beta 1 plays a fundamental role in tissue growth and differentiation involvement in adipogenesis, myogenesis, chondrogenesis, osteogenesis, epithelial cell differentiation and immune cell function.
