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(Pyr¹¹)-beta-Amyloid (11-40)

Supplier: Bachem Americas
Description: pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV, the N-terminally truncated isoform of the amyloid β-protein (Aβ) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid β-protein alloforms it could be observed that among these peptides (Pyr¹¹)-amyloid β-protein (11-40) exhibited the greatest retardation of fibrillization rate.

Image Unavailable-H-4796.0500BA

(Pyr³)-beta-Amyloid (3-42)

Supplier: Bachem Americas
Description: (Pyr³)-Amyloid β-Protein (3-42) was found to be the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. Therefore, (Pyr³)-Aβ (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits. Nussbaum et al. studies the Prion-like behaviour and tau-dependent cytotoxicity of the truncated Aβ sequence.

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Ethyl (R)-(-)-2-pyrrolidone-5-carboxylate 97%

Supplier: Ambeed
Description: H-D-Pyr-OEt, Purity: 97%, CAS Number: 68766-96-1, Appearance: White to yellow powder or crystals, Storage: Sealed in dry, Room Temperature, Size: 100G

Image Unavailable-77089-664

Methyl (S)-(+)-2-pyrrolidone-5-carboxylate 95%

Supplier: Ambeed
Description: Methyl (S)-(+)-2-pyrrolidone-5-carboxylate 95%

New Product

Image Unavailable-L-2145.0025BA

Pyr-Pro-Arg-pNA

Supplier: Bachem Americas
Description: The chromogenic substrate pEPR-pNA has been used for the determination of kinetic constants of tryptase (EC 3.4.21.59) from guinea pig (Km = 0.24 - 0.26 mM) and human (Km = 0.24 - 0.43 mM). Pyr-Pro-Arg-pNA has also been used as substrate for the coagulation factor XIa. Km and kcat values for this substrate were 0.56 mM and 350 s⁻¹, respectively.

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Ethyl-(S)-(+)-2-pyrrolidinone-5-carboxylate 98%

Supplier: Ambeed
Description: Ethyl-(S)-(+)-2-pyrrolidinone-5-carboxylate 98%

Image Unavailable-AAH62543-14

Methyl (S)-(+)-2-pyrrolidone-5-carboxylate 97%

Supplier: Thermo Scientific Chemicals
Description: Methyl (S)-(+)-2-oxopyrrolidine-5-carboxylate, 97%

SDS

Image Unavailable-H-4568.0001BA

Bovine;Human;Mouse;Rat (Pyr¹)-Apelin-13

Supplier: Bachem Americas
Description: The pyroglutamyl form of apelin-13 exhibited a high activity with an EC₅₀ value of 0.30 nM. pERPRLSHKGPMPF is probably the final product of the post-translational modification of apelin and the biologically active endogenous ligand. (Pyr¹)-Apelin-13 has been identified as the predominant apelin isoform in the human heart. Pyr-Apelin-13 stimulates glucose utilization in normal and obese insulin-resistant mice. It could be required for the maintenance of insulin sensitivity.

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(S)-5-Oxopyrrolidine-2-carboxamide 95%

Supplier: Ambeed
Description: (S)-5-Oxopyrrolidine-2-carboxamide 95%

New Product

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Benzyl (S)-1-Boc-5-oxopyrrolidine-2-carboxylate 98%

Supplier: Thermo Scientific Chemicals
Description: Benzyl (S)-1-Boc-5-oxopyrrolidine-2-carboxylate, 98%

SDS Certificates

Image Unavailable-103003-738

Bovine;Human;Mouse;Rat Orexin A

Catalog Number: (103003-738)
Supplier: Anaspec Inc
Description: This hypothalamic neuropeptide has been shown to regulate feeding behavior.
Sequence:Pyr-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: 6-12 and 7-14)
MW:3561.2 Da
% peak area by HPLC:95
Storage condition:-20° C
Image Unavailable-AAAL18359-03

(S)-(+)-5-Hydroxymethyl-2-pyrrolidinone 98%

Supplier: Thermo Scientific Chemicals
Description: L-Pyroglutaminol H-Pyr-ol. Grade: NA. Melting Point C83-85*. Boiling Point C: 147-149*/0. 06mm. C5H9NO2. 17342-08-4. IRRITANT

SDS Certificates

Image Unavailable-103003-710

Caerulein

Catalog Number: (103003-710)
Supplier: Anaspec Inc
Description: Caerulein, a decapeptide analog of the potent pancreatic secretagogue cholecystokinin, stimulates gastric, biliary, and pancreatic secretion. Caerulein injections cause acute pancreatitis in mice.
Sequence: Pyr-QD-Y(SO3H)-TGWMDF-NH2
MW: 1352.4 Da
% Peak area by HPLC: 95
Storage condition:
Product Image-TS23332-0100

Ethyl-(S)-(+)-2-pyrrolidinone-5-carboxylate 99%

Supplier: Thermo Scientific Chemicals
Description: Ethyl-(S)-(+)-2-pyrrolidinone-5-carboxylate 99%

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Human (Leu¹⁵)-Gastrin I

Catalog Number: (103007-868)
Supplier: Anaspec Inc
Description: This human Gastrin-1 analog is functionally the same as the native sequence. However, this analog is more stable.
Sequence: Pyr-GPWLEEEEEAYGWLDF-NH2
MW: 2080.2 Da
% Peak area by HPLC: 95
Storage condition: -20° C
Image Unavailable-102997-272

Human [Pyr3]-beta-Amyloid (3-42)

Supplier: Anaspec Inc
Description: This is one of the predominant amyloid peptide structures deposited in human brain of Alzheimer’s disease and Down’s syndrome patients.Sequence: Pyr-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Molecular Weight: 4309.9 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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