You Searched For: SNS-314

Supplier: Adipogen

Description: Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. The role of Aurora C is unclear; however, Aurora C can complement Aurora B kinase activity in mitosis. SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. A cocrystal structure of SNS-314 with Aurora A confirms that SNS-314 engages the purine-binding pocket of Aurora. SNS-314 inhibits cellular proliferation in the HCT116 colorectal carcinoma cell line with an EC50 of ~5nM. Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. Administration of SNS-314 to HCT116 tumor bearing mice potently suppresses tumor growth. Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent.

Supplier: Ambeed

Description: SNS-314 mesylate ≥98%

New Product

Supplier: Thermo Scientific Chemicals

Description: Coumarin 314 99%, pure

Catalog Number: (77113-698)

Supplier: Ambeed

Description: Ethyl 11-oxo-2,3,5,6,7,11-hexahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinoline-10-carboxylate, Purity: 98%, CAS Number: 55804-66-5, Appearance: Pale-yellow to Yellow-red Powder or Crystals, Storage: Sealed in dry, Room Temperature, Size: 100mg

Catalog Number: (77158-568)

Supplier: Ambeed

Description: 1-Palmitoyl-sn-glycerol, Purity: 95%, CAS Number: 32899-41-5, Appearance: Solid, Storage: Sealed in dry, Room Temperature, Size: 250mg

Catalog Number: (O-1425.0001BA)

Supplier: Bachem Americas

Description: Sequence: 3-Palmitoyl-sn-glycerol
Synonym(s): L-α-Palmitin

Supplier: Bachem Americas

Description: Sequence: sn-Glycero-3-phosphocholine
Synonym(s): Choline alfoscerate#L-α-GPC#L-α-Lecithin

Supplier: Bachem Americas

Description: Sequence: 1-O-Octadecyl-sn-glycerol

Supplier: Ambeed

Description: SN-glycero-3-phosphocholine 98%

New Product

Supplier: Bachem Americas

Description: Sequence: 1,2-Dipalmitoyl-sn-glycerol
Synonym(s): D-α,β-Dipalmitin

Supplier: Bachem Americas

Description: Sequence: 1-O-Hexadecyl-sn-glycero-3-phosphocholine

Supplier: Bachem Americas

Description: Sequence: 1,2-Dimyristoyl-sn-glycerol
Synonym(s): D-α,β-Dimyristin

Supplier: Bachem Americas

Description: Sequence: 1,2-O-Dioctadecyl-sn-glycerol
Synonym(s): D-α,β-Dioctadecyl-glycerol

Catalog Number: (TCC2268-1G)

Supplier: TCI America

Description: CAS Number: 55804-66-5
MDL Number: MFCD00051334
Molecular Formula: C18H19NO4
Molecular Weight: 313.35
Purity/Analysis Method: >98.0% (HPLC,N)
Form: Crystal
Melting point (°C): 150
Lambda max.: 436 nm (EtOH)

SDS

Supplier: Bachem Americas

Description: Sequence: 1,2-O-Dihexadecyl-sn-glycerol
Synonym(s): D-α,β-Dihexadecyl-glycerol

Supplier: Bachem Americas

Description: Sequence: 1,2-Dilauroyl-sn-glycerol
Synonym(s): D-α,β-Dilaurin