You Searched For: PD-0173074

Supplier: BeanTown Chemical

Description: CAS: 7440-05-3; EC No: 231-115-6; MDL No: MFCD00011167; RTECS: RT3480500 Solid; Molecular Formula: Pd; MW: 106.42 Melting Point: 1554°; Boiling Point: 2970° Density (g/mL): 12.02

SDS

Catalog Number: (10765-110)

Supplier: Prosci

Description: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.

Supplier: BeanTown Chemical

Description: CAS: 21797-13-7; MDL No: MFCD00043297 UN No: UN2811; Haz Class: 6.1; Packing Group: III Powder; Linear Formula: Pd(CH3CN)4(BF4)2; Molecular Formula: C8H12B2F8N4Pd; MW: 444.22 Melting Point: 230° (decomposes) Air Sensitive, Moisture Sensitive

SDS

Supplier: BeanTown Chemical

Description: CAS: 7440-05-3; EC No: 231-115-6; MDL No: MFCD00011167 Solid; Molecular Formula: Pd; MW: 106.42 Melting Point: 1554°; Boiling Point: 2970° Density (g/mL): 12.02

SDS

Supplier: Ambeed

Description: MorDalPhos Pd G4 ≥98%

New Product

Catalog Number: (76198-898)

Supplier: Genscript

Description: The product is specific for human PD-1 (UniProt Accession: Q15116). This antibody blocks human PD-L1 binding with human PD-1 expression cell line in flow cytometry assay.

Supplier: Ambeed

Description: [2'-(Amino-κN)[1,1'-biphenyl]-2-yl-κC][[2'-(diphenylphosphino)[1,1'-binaphthalen]-2-yl]diphenylphosphine-κP](methanesulfonato-κO)palladium 98%

New Product

Supplier: Abcam

Description: Human PD-L1 ELISA Kit [28-8]

New Product

Catalog Number: (75791-560)

Supplier: Prosci

Description: Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. This family also include members of CD28, CTLA-4 and ICOS.The mouse Programmed Death-1 protein, encoded by PD-1 gene, comprises four parts including a putative 20 aa signal peptide, a 149 aa extracellular region, a 21 aa transmembrane domain and a 98 aa cytoplasmic region. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating. Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner. PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.

Catalog Number: (75843-274)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.

Catalog Number: (AA46383-03)

Supplier: Thermo Scientific Chemicals

Description: Dichloro[1,1'-bis(dicyclohexylphosphino)ferrocene]palladium(II), Pd 14.1%

SDS Certificates

Supplier: TCI America

Description: CAS Number: 31277-98-2
MDL Number: MFCD00009880
Molecular Formula: C52H48P4Pd
Molecular Weight: 903.27
Purity/Analysis Method: >96.0% (T)
Form: Crystal
Storage Temperature: >-20°C

SDS

Catalog Number: (76411-358)

Supplier: KLEN INTERNATIONAL (74) PTY LTD.

Description: KLEN's CRMs are certified products containing a range of analytes including Au, Ag, Pt, and Pd at various ppm levels

SDS Certificates

Catalog Number: (76163-666)

Supplier: Prosci

Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2). PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells (3). This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. PD-L1 also functions as an immune checkpoint protein, and multiple anti-PD-L1 antibodies are currently in phase II and III clinical trials, with one antibody already approved for the treatment of cancer (4).

Catalog Number: (76163-662)

Supplier: Prosci

Description: PD-L2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.

Catalog Number: (76163-660)

Supplier: Prosci

Description: PD-L2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.