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AdipoRon ≥98% (by NMR)

Supplier: Adipogen
Description: Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.

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DMNQ ≥99% (by NMR)

Supplier: Adipogen
Description: Cell permeable, non-alkylating, non-thiol, adduct-forming, redox cycling quinone. Intracellular superoxide anion formation/ROS generation inducer. Anticancer agent. Shown to induce cell proliferation, apoptosis, necrosis and necroptosis in vitro, dependent on concentration, time, temperature and cell type. Valuable tool for the generation of reactive oxygen species (ROS) in order to study the role of ROS in cell toxicity, apoptosis and necrosis. Useful as reference compound in characterizing the effects of oxidative stress. Can be used to eliminate any mechanistic ambiguity involving redox cycling quinoids as the source of reactive oxidant species/oxidative stress in biological studies.

Image Unavailable-AA42319-KV

Methanol-[D₄] (99.8% D) (Isotopic) + 0.05% v/v TMS for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00044637

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Image Unavailable-102989-134

7-Amino-4-methylcoumarin

Supplier: Adipogen
Description: Widely used fluorophore well-known for preparing fluorogenic 7-Amido-4-methylcoumarin (AMC) substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.

Product Image-PAV1201

2-Morpholino-8-phenylchromone

Catalog Number: (PAV1201)
Supplier: Promega Corporation
Description: LY 294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinases (PI 3-kinases).

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Pioglitazone ≥98% (by 1H-NMR)

Supplier: Adipogen
Description: Thiazolidinedione (TZD) reference compound. Selective PPARgamma agonist. Selectively activates PPARgamma-1. Anti-diabetic , decreasing insulin resistance in adipose tissue. Is about one tenth as potent as rosiglitazone. Lipid metabolism modulator. Estrogen synthesis inhibitor. NF-kappaB inhibitor. Neuroprotective.

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Image Unavailable-AA42318-KV

Methanol-[D₄] (99.8% D) (Isotopic) for NMR spectroscopy

Catalog Number: (AA42318-KV)
Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00044637

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Image Unavailable-AA42335-KV

Dichloromethane-[D₂] (99.9% D) (Isotopic) for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00000882

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Image Unavailable-102516-212

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one ≥98% (by NMR)

Supplier: Adipogen
Description: Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC). The binding is competitive with nitric oxide (NO). Tool to elucidate the nitric oxide (NO)-cGMP pathway. Apoptosis inhibitor Inhibits growth and migration of prostate cancer cells independent of its effects on GMP levels.

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Trifluoroacetic acid-[D₁] 99.5 atom % D for NMR spectroscopy

Catalog Number: (TS325330100)
Supplier: Thermo Scientific Chemicals
Description: Packaged in 1 ml ampoules

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D-(-)-N-Methylglucamine ≥95% (by NMR)

Supplier: Adipogen
Description: Used as an excipient (an inert substance) in pharmaceuticals that improves solubility, drug release rate and stabilization of anionic drug substances. Counter ion used to replace sodium. It is impermeable towards cell membranes with comparable osmotic activity like sodium. Widely used in the preparation of contrast/radiopaque media in combination with iodine containing compounds, such as diatrizoate meglumine and iodipamide meglumine. Examples of meglumine-combined drugs are flunixin meglumine (used as a veterinary anti-inflammatory and analgesic) and meglumine antimoniate (antiprotozoal to treat leishmaniasis).

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(R)-Roscovitine ≥99% (by NMR)

Catalog Number: (102987-460)
Supplier: Adipogen
Description: Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Pyridoxal kinase (PDXK) inhibitor. Triggers cell apoptotic cell death. Down-regulates Mcl-1 and MYCN. Anticancer compound. Kills chronic lymphocytic leukemia (LLC) cells and slows tumor growth in mouse xenografts. Inhibits cysts formation in culture and in polycystic kidney disease (PKD) mouse models. Potential anti-inflammatory compound that can influence the resolution of inflammation. Potential antidiabetic compound. Shown to protect pancreatic beta-cells from glucotoxicity and increase insulin secretion. Shows antiviral properties. Neuroprotective in brain trauma. Has positive effects on Timothy syndrome cells. Used for cloning of mammals by synchronization of nucleus donor cells. Provides neuroprotection in experimental traumatic brain injury.
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Acetonitrile-[D₃] (100% D) (Isotopic) for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00001881 Notes: Minimum isotopic purity, 99.96%

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Image Unavailable-AA42334-KV

Dichloromethane-[D₂] (100% D) (Isotopic) for NMR spectroscopy

Catalog Number: (AA42334-KV)
Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00000882 Notes: Minimum isotopic purity 99.96%

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Image Unavailable-AA42264-18

Acetonitrile-[D₃] (99.8% D) (Isotopic) for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00001881

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Image Unavailable-102516-002

MS-275 ≥98% (by NMR)

Supplier: Adipogen
Description: HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Review. Promotes either self-renewal or differentiation of embryonic stem cells.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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