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Methanol-[D₄] (99.8% D) (Isotopic) + 0.05% v/v TMS for NMR spectroscopy

Supplier: Thermo Scientific Chemicals

Description: MDL: MFCD00044637

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7-Amino-4-methylcoumarin

Supplier: Adipogen

Description: Widely used fluorophore well-known for preparing fluorogenic 7-Amido-4-methylcoumarin (AMC) substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.

2-Morpholino-8-phenylchromone

Catalog Number: (PAV1201)

Supplier: Promega Corporation

Description: LY 294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinases (PI 3-kinases).

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Pioglitazone ≥98% (by 1H-NMR)

Supplier: Adipogen

Description: Thiazolidinedione (TZD) reference compound. Selective PPARgamma agonist. Selectively activates PPARgamma-1. Anti-diabetic , decreasing insulin resistance in adipose tissue. Is about one tenth as potent as rosiglitazone. Lipid metabolism modulator. Estrogen synthesis inhibitor. NF-kappaB inhibitor. Neuroprotective.

Methanol-[D₄] (99.8% D) (Isotopic) for NMR spectroscopy

Catalog Number: (AA42318-KV)

Supplier: Thermo Scientific Chemicals

Description: MDL: MFCD00044637

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Dichloromethane-[D₂] (99.9% D) (Isotopic) for NMR spectroscopy

Supplier: Thermo Scientific Chemicals

Description: MDL: MFCD00000882

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1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one ≥98% (by NMR)

Supplier: Adipogen

Description: Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC). The binding is competitive with nitric oxide (NO). Tool to elucidate the nitric oxide (NO)-cGMP pathway. Apoptosis inhibitor Inhibits growth and migration of prostate cancer cells independent of its effects on GMP levels.

AdipoRon ≥98% (by NMR)

Supplier: Adipogen

Description: Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.

DMNQ ≥99% (by NMR)

Supplier: Adipogen

Description: Cell permeable, non-alkylating, non-thiol, adduct-forming, redox cycling quinone. Intracellular superoxide anion formation/ROS generation inducer. Anticancer agent. Shown to induce cell proliferation, apoptosis, necrosis and necroptosis in vitro, dependent on concentration, time, temperature and cell type. Valuable tool for the generation of reactive oxygen species (ROS) in order to study the role of ROS in cell toxicity, apoptosis and necrosis. Useful as reference compound in characterizing the effects of oxidative stress. Can be used to eliminate any mechanistic ambiguity involving redox cycling quinoids as the source of reactive oxidant species/oxidative stress in biological studies.

D-(-)-N-Methylglucamine ≥95% (by NMR)

Supplier: Adipogen

Description: Used as an excipient (an inert substance) in pharmaceuticals that improves solubility, drug release rate and stabilization of anionic drug substances. Counter ion used to replace sodium. It is impermeable towards cell membranes with comparable osmotic activity like sodium. Widely used in the preparation of contrast/radiopaque media in combination with iodine containing compounds, such as diatrizoate meglumine and iodipamide meglumine. Examples of meglumine-combined drugs are flunixin meglumine (used as a veterinary anti-inflammatory and analgesic) and meglumine antimoniate (antiprotozoal to treat leishmaniasis).

(R)-Roscovitine ≥99% (by NMR)

Catalog Number: (102987-460)

Supplier: Adipogen

Description: Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5, CDK7 and CDK9. Pyridoxal kinase (PDXK) inhibitor. Triggers cell apoptotic cell death. Down-regulates Mcl-1 and MYCN. Anticancer compound. Kills chronic lymphocytic leukemia (LLC) cells and slows tumor growth in mouse xenografts. Inhibits cysts formation in culture and in polycystic kidney disease (PKD) mouse models. Potential anti-inflammatory compound that can influence the resolution of inflammation. Potential antidiabetic compound. Shown to protect pancreatic beta-cells from glucotoxicity and increase insulin secretion. Shows antiviral properties. Neuroprotective in brain trauma. Has positive effects on Timothy syndrome cells. Used for cloning of mammals by synchronization of nucleus donor cells. Provides neuroprotection in experimental traumatic brain injury.