AdipoRon ≥98% (by NMR)
Supplier: ADIPOGEN CORP MS
Synonyms:
SC-396658, 2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide, 2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.
Formula:
C₂₇H₂₈N₂O₃ MW: 428.52 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD08271060 CAS Number: 924416-43-3 |
Specification Test Results
Purity | >98% (NMR) |
Appearance/Color | White solid. |
Solubility | Soluble in DMSO, 100% ethanol or methanol. Insoluble in water. |
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