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N-Hexanoyl-L-homoserine lactone ≥98% (by NMR)

Supplier: Adipogen
Description: N-Hexanoyl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression and affecting cellular metabolism. The diverse applications of this molecule include regulation of virulence in general and in cystic fibrosis, infection prevention, slime and biofilm reduction in commercial agriculture and aquaculture industries, food spoilage prevention and septicemia in fish.

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Fluorescin

Supplier: Adipogen
Description: Fluorescent probe in biology used to detect protein location and activation, identify protein complex formation and conformational changes and monitor biological processes in vitro or in vivo.

Image Unavailable-77401-232

Chloroform-[D₁] (>99,80% D) for NMR spectroscopy (max. 0.03% TMS (tetramethylsilan))

Catalog Number: (77401-232)
Supplier: APOLLO SCIENTIFIC
Description: (H2O)<0.01%
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Bisindolylmaleimide III ≥98% (by NMR)

Supplier: Adipogen
Description: Potent and selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2).

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SIN-1 chloride ≥98% (by NMR)

Supplier: Adipogen
Description: Nitric oxide (NO) donor. Generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite. Platelet aggregation inhibitor. Guanylyl cyclase activator. Cytotoxic. Positive ionotropic. Vasodilator.

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Image Unavailable-102599-126

TSAT (Tris-(succinimidyl)aminotriacetate) ≥99% (by NMR), Sigma-Aldrich®

Catalog Number: (102599-126)
Supplier: Chem Impex International
Description: Crosslinking agent for compounds carrying an amino group
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alpha-NETA ≥97% (by NMR)

Supplier: Adipogen
Description: Potent fluorescent inhibitor of choline acetyltransferase. CMKLR1 antagonist. Inhibits chemerin-stimulated beta-arrestin2 association with CMKLR1, as well as chemerin-triggered CMKLR1+ cell migration. Aldehyde dehydrogenase 1 (ALDH1A1) antagonist.

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Image Unavailable-AA42348-KV

Tetrahydrofuran-[D₈] (100% D) (Isotopic) for NMR spectroscopy

Catalog Number: (AA42348-KV)
Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00044238

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7-Azido-4-methylcoumarin ≥98% (by NMR)

Supplier: Adipogen
Description: Highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex = 365 nm and lambdaem = 450 nm. Photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). Probe to monitor the enzymatic production of H2S in vitro and to visualize H2S in living cells. Tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)). Tool to identify novel cystathionine beta-synthase (CBS) inhibitors and activators. Suitable for high-throughput screening. Caution: Use of this product with DTT, TCEP and/or biological thiols at concentrations of >25 mM should be avoided for maximum efficiency.

Product Image-89147-906

AMI-1 ≥98% (by 1H-NMR, HPLC)

Catalog Number: (89147-906)
Supplier: Enzo Life Sciences
Description: PRMT inhibitor
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Ketanserin tartrate ≥98% (by NMR)

Supplier: Adipogen
Description: Selective 5-HT2A serotonin receptor antagonist. ATP-sensitive potassium channel inhibitor. hERG potassium channel blocker.

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AdipoRon hydrochloride hydrate ≥98% (by HPLC, NMR)

Supplier: Adipogen
Description: Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.

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(2'Z,3'E)-6-Bromoindirubin-3'-oxime ≥99% (by NMR)

Supplier: Adipogen
Description: Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Anticancer compound. Potent antiproliferative agent. Suppresses metastasis. Apoptosis inducer. Sustains pluripotency and self-renewal of human and mouse embryonic stem cells (ESCs) by activation of the Wnt signaling pathway. Anti-leishmanial (IC50 = 0.150µM). Proto-oncogene tyrosine-protein kinase receptor RET inhibitor (IC50=0.51µM). Inhibits HIV-1 transcription and protects against Tat induced neurotoxicity.

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Paprotrain ≥98% (by NMR)

Catalog Number: (102516-224)
Supplier: Adipogen
Description: Cell permeable and reversible kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor. Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation. Moderate DYRK1A inhibitor (IC50= 5.5 µM). Lead compound.

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MK-571 sodium salt ≥97% (by NMR)

Supplier: Adipogen
Description: Selective leukotriene LTD4 receptor antagonist. Potent MRP1 inhibitor. Antinociceptive.

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GV-58 ≥97% (by NMR)

Supplier: Adipogen
Description: Selective N- and P/Q-type Ca2+-channel agonist. These Ca2+-channels regulate transmitter release in synapses. Potential lead compound for a variety of disorders that result in neuromuscular weakness.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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