(2'Z,3'E)-6-Bromoindirubin-3'-oxime ≥99% (by NMR)
Supplier: ADIPOGEN CORP MS
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Warning
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Synonyms:
GSK 3 Inhibitor IX, BIO, 6BIO, 6-Bromoindirubin-3'-oxime, (2Z,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Anticancer compound. Potent antiproliferative agent. Suppresses metastasis. Apoptosis inducer. Sustains pluripotency and self-renewal of human and mouse embryonic stem cells (ESCs) by activation of the Wnt signaling pathway. Anti-leishmanial (IC50 = 0.150µM). Proto-oncogene tyrosine-protein kinase receptor RET inhibitor (IC50=0.51µM). Inhibits HIV-1 transcription and protects against Tat induced neurotoxicity.
Formula:
C₁₆H₁₀BrN₃O₂ MW: 356.18 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD08705318 CAS Number: 667463-62-9 |
Specification Test Results
Purity |
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Appearance/Color | Dark red solid. |
Solubility | Soluble in DMSO or ethanol. |
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