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Dimethyl sulfoxide-[D₆] (100% D) (Isotopic) for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00002090 Notes: Minimum isotopic purity 99.96%

SDS Certificates

Image Unavailable-AA42291-03

1,1,1,3,3,3-Hexafluoro-2-propanol-[D₂] (98% D) (Isotopic) for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: 98% (Isotopic),UN1760,Liquid, packaged in prescored ampoules,DANGER: CORROSIVE, irritates skin & eyes,5x1g,1g,CORROSIVE,

SDS Certificates

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Dimethyl sulfoxide-[D₆] (100% D) (Isotopic) + 0.03% v/v TMS for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00002090 Minimum isotopic purity 99.96%

SDS Certificates

Image Unavailable-102516-020

Alsterpaullone ≥98% (by NMR)

Supplier: Adipogen
Description: Potent CDK1/cyclin B (IC50 = 35 nM) inhibitor. Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E (IC50 = 200 nM), CDK5/p25 (IC50 = 40 nM), CDK5/p35 (IC50 = 40 nM). GSK-3beta (glycogen synthase kinase-3beta) inhibitor. Apoptosis inhibitor. Apoptosis inducer. Angiogenesis inhibitor.

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RO-3306 ≥95% (by NMR)

Supplier: Adipogen
Description: Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M·Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards.

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2-Morpholino-8-phenylchromone ≥99% (by NMR)

Supplier: Adipogen
Description: Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor. pan-class I / II / III PI3K inhibitor. Acts on the ATP-binding site of the enzyme. In solution more stable than wortmannin. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Autophagy inhibitor (autophagosome formation). Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4.

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Image Unavailable-89139-292

4-Bromo-A-23187 free acid ≥98% (by TLC, NMR) ionophore, for calcium determination

Catalog Number: (89139-292)
Supplier: Biotium
Description: Similar to A-23187, 4-Bromo A-23187 is used for in situ calibrations of fluorescent Ca2 indicators to equilibrate intracellular and extracellular calcium concentrations and to allow Mn2 to enter cells to quench indicator fluorescence. However, since 4-bromo A-23187 is nonfluorescent, it is preferred over the blue fluorescent A-23187 for calibrations of UV-excited Ca2 indicators such as Indo-1 and Fura-2 in order to keep background fluorescence to a minimum.
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L-4-Cyanophenylalanine 98% (by NMR)

Supplier: Thermo Scientific Chemicals
Description: 4-Cyano-L-phenylalanine, 98%

SDS Certificates

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Nocodazole ≥98% (by NMR)

Supplier: Adipogen
Description: Microtubule inhibitor. Antitumor compound. Mitosis inhibitor. Arrests the cell cycle at G2/M phase. Promotes tubulin depolymerization. Induces fragmentation of the Golgi complex. Inhibits the T cell antigen receptor. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway. Apoptosis inducer. Autophagy inhibition through prevention of autophagosome-lysosome fusion.

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H-89 dihydrochloride ≥98% (by NMR)

Supplier: Adipogen
Description: Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cµ (PKCµ) inhibitor. Ca2+/calmodulin-dependent protein kinase II inhibitor. Casein kinase I inhibitor. Myosin light chain kinase (MLCK) inhibitor. Apoptosis enhancer. Tool to study protein crystal structure-inhibitor interactions. Rho kinase inhibitor. Cell proliferation inhibitor. Review.

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Product Image-89147-930

4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinoline ≥97% (by 1H-NMR)

Catalog Number: (89147-930)
Supplier: Enzo Life Sciences
Description: Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=51nM). Displays ~15-fold greater selectivity over p38α MAPK (IC50=740nM). Inhibits TGF-β-dependent cellular growth (IC50=89nM in NIH 3T3 mouse fibroblasts) and transcription activation (IC50=47nM in mink lung cells). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.
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2-Propanol-[D₈] (99% D) (Isotopic) for NMR spectroscopy

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00044341

SDS Certificates

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KN-93 phosphate ≥98% (by 1H-NMR)

Supplier: Enzo Life Sciences
Description: CaM kinase II inhibitor

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Bisindolylmaleimide I ≥98% (by NMR)

Supplier: Adipogen
Description: Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Promotes osteoblastogenesis in human mesenchymal stem cells.

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Product Image-PI21580

BS3 (Bis(sulfosuccinimidyl) suberate sodium salt) ≥93% (by NMR), Pierce™

Supplier: Invitrogen
Description: Thermo Scientific Pierce BS3 (Sulfo-DSS) is bis(sulfosuccinimidyl)suberate, an amine-to-amine crosslinker that is homobifunctional, water-soluble, non-cleavable and membrane impermeable.

SDS Certificates

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GYY 4137 ≥95% (by NMR)

Supplier: Adipogen
Description: Water-soluble, slow-releasing hydrogen sulfide (H2S) donor. Exhibits vasodilator and antihypertensive activity. Anti-inflammatory. Inhibits LPS-induced release of proinflammatory mediators (IL-1beta, IL-6, TNF-alpha, nitric oxide (NO) and PGE2) and increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-kappaB, ATF-2 and HSP27 dependent pathways. Causes stomatal opening and reduces nitric oxide accumulation in plants. Oxidative stress-induced cell death inhibitor. Shows novel anti-cancer effects in vitro and in vivo. Anti-thrombotic via p-selectin dependent mechanism.

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