You Searched For: Lipid+A

Catalog Number: (76427-122)

Supplier: VWR International

Description: Application specific column for lipids, sterols and triglycerides analysis.

Catalog Number: (470138-074)

Supplier: VWR International

Description: This model of the HIV virus is enlarged millions of times to show the outer lipid membrane with protein structures and the internal nucleoproteins and contained RNA.

Catalog Number: (76002-224)

Supplier: Enzo Life Sciences

Description: TLR4 activator.

Supplier: Enzo Life Sciences

Description: TLR4 activator.

Supplier: Adipogen

Description: Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4), a member of the highly conserved protein family of TLRs, which are specialised in the recognition of microbial components. In mice, defects in TLR4 result in LPS unresponsiveness. For optimal interaction with LPS, TLR4 requires association with myeloid differentiation protein 2 (MD-2). According to current consensus activation of TLR4 is preceded by the transfer of LPS to membrane-bound (m) or soluble (s) CD14 by LPS-binding protein (LBP). This mechanism is believed to be generally true for LPS signaling. Re-form LPS and lipid A, but not S-form LPS, are capable of inducing TNF-alpha responses also in the absence of CD14. LPS, synthesized by most wild-type (WT) Gram-negative bacteria (S-form LPS), consists of three regions, the O-polysaccharide chain, which is made up of repeating oligosaccharide units, the core oligosaccharide and the lipid A, which harbors the endotoxic activity of the entire molecule. R-form LPS synthesized by the so-called rough (R) mutants of Gram-negative bacteria lacks the O-specific chain. Furthermore, the core-oligosaccharide may be present in different degrees of completion, depending on the class (Ra to Re) to which the mutant belongs. Monophosphoryl Lipid A (MPLA) represents a detoxified derivative of Lipid A and constitutes an important adjuvant in prophylactic and therapeutic vaccines.

Supplier: Adipogen

Description: Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4), a member of the highly conserved protein family of TLRs, which are specialised in the recognition of microbial components. In mice, defects in TLR4 result in LPS unresponsiveness. For optimal interaction with LPS, TLR4 requires association with myeloid differentiation protein 2 (MD-2). According to current consensus activation of TLR4 is preceded by the transfer of LPS to membrane-bound (m) or soluble (s) CD14 by LPS-binding protein (LBP). This mechanism is believed to be generally true for LPS signaling. Re-form LPS and lipid A, but not S-form LPS, are capable of inducing TNF-alpha responses also in the absence of CD14. LPS, synthesized by most wild-type (WT) Gram-negative bacteria (S-form LPS), consists of three regions, the O-polysaccharide chain, which is made up of repeating oligosaccharide units, the core oligosaccharide and the lipid A, which harbors the endotoxic activity of the entire molecule. R-form LPS synthesized by the so-called rough (R) mutants of Gram-negative bacteria lacks the O-specific chain. Furthermore, the core-oligosaccharide may be present in different degrees of completion, depending on the class (Ra to Re) to which the mutant belongs. Monophosphoryl Lipid A (MPLA) represents a detoxified derivative of Lipid A and constitutes an important adjuvant in prophylactic and therapeutic vaccines.

Catalog Number: (102987-458)

Supplier: Adipogen

Description: Toll-like receptor 4 (TLR4) activator. Activates TLR4 but does not activate TLR2 even at high concentrations. Defined structure of MPLA. Synthetic lipid A is structurally very similar to natural MPLA but does not exist in nature.
Formula: C96H184N3O22P
MW: 1763.47
CAS: 1246298-63-4
Source/Host Chemicals: Synthetic. Does not contain RNA, DNA or protein fragments.
Purity: No detectable TLR4 independent activity: standardised TLR4-specific agonist.
Appearance: Colourless opaque aqueous solution.
Formulation: Liquid.
Concentration: 0.5mg/ml stabilized in sterile, double-distilled water (ddWater), without any additives.
Other Product Data: Preparation of Stock Solution: To yield a 50µg/ml (500-50x) stock solution add 100µl of MPLA to 900µl endotoxin-free and sterile ddWater (Cat. No.: IAX-900-002) (not PBS) and mix well.

Catalog Number: (102516-340)

Supplier: Adipogen

Description: Defined substructure of the Re mutant of lipopolysaccharide (LPS). Endotoxin activity equal to Re LPS. Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA. Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 and CD14. Kdo2-Lipid A was used in a recent animal atherosclerosis model. Induces sphingolipid biosynthesis, which is essential for induction of autophagy.

Catalog Number: (76484-484)

Supplier: AAT BIOQUEST INC

Description: Lipid droplets, also referred to as lipid bodies, oil bodies or adiposomes, are lipid-rich cellular organelles that regulate the storage and hydrolysis of neutral lipids.

Supplier: Audit Microcontrols

Description: Universal linearity lipids, linearity lipids for Roche Systems, and linearity lipids for Beckman AU are assayed quality control materials consisting of five levels of bovine based serum albumin.

Supplier: Sino Biological

Description: The substrate solution used for assaying lipid kinases.

New Product

Catalog Number: (76711-910)

Supplier: AFG BIOSCIENCE LLC

Description: Human Lipid Peroxide(LPO) ELISA Kit

Supplier: Sino Biological

Description: The substrate solution used for assaying lipid kinases.

New Product

Supplier: Cell Biolabs

Description: Cell Biolabs' Lipid Quantitation Kit provides a simple method for quantitation of unsaturated fatty acids from plasma, serum, or cultured cells in a standard 96-well microplate reader

Supplier: Sino Biological

Description: The working solution used for diluting lipid substrates.

New Product

Catalog Number: (76714-632)

Supplier: AFG BIOSCIENCE LLC

Description: Human Lipid Peroxidation (LPO) ELISA Kit