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You Searched For: IKK+Inhibitor+VI


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Product Image-76293-028

IKK Inhibitor VI ≥95%

Supplier: Cayman Chemical Company
Description: IKK2 Inhibitor VI, Purity >/=95%, CAS 354811-10-2, MF: C12H11N3O2S, MW: 261.3, Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide, 2-[(aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide, Formulation: A crystalline solid, Storage: -20C, Size: 500ug

Image Unavailable-AAJ65132-MA

IKK-2 inhibitor V

Catalog Number: (AAJ65132-MA)
Supplier: Thermo Scientific Chemicals
Description: A selective IKK-2 inhibitor

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Image Unavailable-76293-038

IKK-2 ≥98%

Supplier: Cayman Chemical Company
Description: IMD 0354, Purity >/=98%, CAS 978-62-1, MF: C15H8ClF6NO2, MW: 383.7, Synonyms: IKK2 Inhibitor V, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-benzamide, Formulation: A crystalline solid, Size: 10mg

Image Unavailable-76293-036

IKK-16 (hydrochloride) ≥95%

Supplier: Cayman Chemical Company
Description: IKK-16 (hydrochloride), Purity >/=98%, CAS 1186195-62-9, MF: C28H29N5OS.HCl, MW: 520.1, Synonyms: IKK Inhibitor VII, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone, monohydrochloride, crystalline, Size: 5mg

Image Unavailable-80050-802

Caspase-1 Inhibitor VI, Calbiochem®

Supplier: MilliporeSigma
Description: A potent, cell-permeable, and irreversible inhibitor of caspase-1 (ICE) and caspase-4.

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Product Image-10069-028

Anti-IKBKB Rabbit Polyclonal Antibody

Catalog Number: (10069-028)
Supplier: Prosci
Description: Acts as part of the IKK complex in the conventional pathway of NF-κ-B activation and phosphorylates inhibitors of NF-κ-B thus leading to the dissociation of the inhibitor/NF-κ-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.
Product Image-76714-460

Human Inhibitor of Nuclear Factor Kappa-B Kinaseα(IKK-α) ELISA Kit

Catalog Number: (76714-460)
Supplier: AFG BIOSCIENCE LLC
Description: Human Inhibitor of Nuclear Factor Kappa-B Kinaseα(IKK-α) ELISA Kit
Image Unavailable-77439-660

Anti-IKK Gamma Rabbit Polyclonal Antibody

Catalog Number: (77439-660)
Supplier: Bioss
Description: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity (By similarity). Essential for viral activation of IRF3.

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Product Image-76657-028

IKK-16 (hydrochloride) 98%

Supplier: Ambeed
Description: (4-((4-(Benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone hydrochloride, Purity: 98%, CAS Number: 1186195-62-9, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 10MG

Product Image-89158-130

SC-514 ≥98% (by TLC)

Supplier: Enzo Life Sciences
Description: IKK inhibitor

Product Image-89161-290

IKK-NBD peptide

Catalog Number: (89161-290)
Supplier: Enzo Life Sciences
Description: NF-kappaB inhibitor
Image Unavailable-102979-958

Anti-Nuclear Factor NF-kappaB Essential Modulator;NEMO;IKKG;FIP-3 Rabbit Polyclonal Antibody

Catalog Number: (102979-958)
Supplier: Adipogen
Description: IKK-gamma is the regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappaB, thus leading to the dissociation of the inhibitor/NF-kappaB complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. IKK-gamma is also considered to be a mediator for TAX activation of NF-kappaB and it could be implicated in NF-kappaB-mediated protection from cytokine toxicity. It is essential for viral activation of IRF3 and is involved in TLR3- and IFIH1-mediated antiviral innate response.
Image Unavailable-10354-664

Anti-IKK beta Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10354-664)
Supplier: Bioss
Description: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Product Image-76292-966

BMS 345541 (trifluoroacetate salt) ≥98%

Supplier: Cayman Chemical Company
Description: BMS 345541 (trifluoroacetate salt), Purity >/=98%, MF: C14H17N5.2CF3COOH, MW: 483.4, Synonyms: IKK Inhibitor III, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine, trifluoroacetate salt, Formulation: crystalline, Storage: -20C, Size: 10mg

Product Image-10068-838

Anti-CHUK Rabbit Polyclonal Antibody

Catalog Number: (10068-838)
Supplier: Prosci
Description: Acts as part of the IKK complex in the conventional pathway of NF-κ-B activation and phosphorylates inhibitors of NF-κ-B thus leading to the dissociation of the inhibitor/NF-κ-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-κ-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-κ-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-κ-B-regulated promoters during inflammatory responses triggered by cytokines.
Image Unavailable-76082-116

Anti-IKK beta Tyr199 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76082-116)
Supplier: Bioss
Description: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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