You Searched For: Ganglioside+GD3+disodium+salt


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Supplier: Adipogen
Description: Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD3 induces mitochondrial permeability transition (MPT) without requiring elevated Ca2+ levels and thus triggers Fas-mediated apoptosis. It modulates the activity of Src-family tyrosine kinase Lyn and cell apoptosis. It is involved in several tumor processes and is high abundant in proliferating cells and in the first stage of neuronal differentiation.

Supplier: Enzo Life Sciences
Description: Induces mitochondrial permeability transition (MPT) without requiring elevated Ca2+ levels and thus triggers Fas-mediated apoptosis.

Catalog Number: (102988-414)
Supplier: Adipogen
Description: Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1b may act as a bacterial toxin receptor (tetanus, botulinus). High levels are found in gliomas and astrocytomas. It modulates protein kinase activities. In vivo and in vitro it is in equilibrium with the lactone structure.


Supplier: Adipogen
Description: Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1a is the major ganglioside of the nervous system. It is converted to GM1 by bacterial, viral and mammalian sialidases. It is a differentiation marker for cell growth.

Supplier: Enzo Life Sciences
Description: Differentiation marker for cell growth. Protein kinase C (PKC) inhibitor. The major ganglioside of the nervous system.

Catalog Number: (76710-900)
Supplier: AFG BIOSCIENCE LLC
Description: Human Anti Ganglioside D3 (GD3) Antibody ELISA Kit


Catalog Number: (89148-656)
Supplier: Enzo Life Sciences


Catalog Number: (103462-446)
Supplier: Affymetrix, Inc.
Description: MA1-25302 detects Ganglioside GD3 from human samples. MA1-25302 has been successfully used in immunohistochemistry (frozen) procedures. Positive control of human melanoma suggested. The MA1-25302 immunogen is SK-MEL-28 Melanoma cell line

Blocked

Catalog Number: (102901-990)
Supplier: Affymetrix, Inc.
Description: The monoclonal antibody MB3.6 recognizes human disialoganglioside GD3, a membrane-bound sialic acid-containing glycosphingolipid. Gangliosides are synthesized in the Golgi apparatus by glycosyltransferases before localizing to the plasma membrane. Gangliosides function as receptors for growth factors and hormones as well as mediating interaction with adhesion molecules at the surface of all cells. GD3 is expressed at low levels in retina pigment cells and melanocytes. Elevated GD3 levels are found in neural stem cells, epithelial-origin tumor cells (cervical, ovarian, prostate, breast, and skin), as well as T-cell leukemic lymphoblasts (T-ALL). The GD3 monoclonal antibody has been reported to fix complement and induce antibody-dependent cytotoxicity of melanoma cell lines. Applications Reported: This MB3.6 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, and immunocytochemistry. Applications Tested: This MB3.6 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low or high pH antigen retrieval and can be used at less than or equal to 5 µg/mL. This MB3.6 antibody has been tested by immunocytochemistry of formaldehyde-fixed cells and can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Disialoganglioside GD3 is a membrane-bound sialic acid-containing glycosphingolipid. Gangliosides are synthesized in the Golgi apparatus by glycosyltransferases before localizing to the plasma membrane. Gangliosides function as receptors for growth factors and hormones as well as mediating interaction with adhesion molecules at the surface of all cells. GD3 is expressed at low levels in retina pigment cells and melanocytes. Elevated GD3 levels are found in neural stem cells, epithelial-origin tumor cells (cervical, ovarian, prostate, breast, and skin), as well as T-cell leukemic lymphoblasts (T-ALL).

Blocked

Catalog Number: (TCA2580-VIAL)
Supplier: TCI America
Description: Purified mouse monoclonal antibody/IgM, κ-chain

SDS


Catalog Number: (102116-800)
Supplier: Novus Biologicals
Description: The ST8 alpha-2,8-Sialyltransferase 8A / ST8SIA1 / Ganglioside GD3 Antibody from Novus Biologicals is a chicken polyclonal antibody to ST8 alpha-2,8-Sialyltransferase 8A / ST8SIA1 / Ganglioside GD3. This antibody reacts with human. The ST8 alpha-2,8-Sialyltransferase 8A / ST8SIA1 / Ganglioside GD3 Antibody has been validated for the following applications: Western Blot.


Catalog Number: (75909-534)
Supplier: Biotium
Description: This MAb reacts with 9-O-acetylated disialosyl group linked to the glycoprotein CD60w. CDw60 is a carbohydrate antigen present on gangliosides, platelets and a subset of CD4 , CD8 peripheral T-cells, but not on B-cells, monocytes or granulocytes. CDw60 is involved in the co-stimulation of T-cells.


Supplier: Biotium
Description: This MAb reacts with 9-O-acetylated disialosyl group linked to the glycoprotein CD60w. CDw60 is a carbohydrate antigen present on gangliosides, platelets and a subset of CD4 , CD8 peripheral T-cells, but not on B-cells, monocytes or granulocytes. CDw60 is involved in the co-stimulation of T-cells.

Catalog Number: (102868-642)
Supplier: R&D Systems
Description: The Recombinant Human ST8SIA1 Protein from R&D Systems is derived from CHO. The Recombinant Human ST8SIA1 Protein has been validated for the following applications: Enzyme Activity.


Catalog Number: (102988-404)
Supplier: Adipogen
Description: Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM2 is a very minor component of the nervous system, but it is accumulated in brains from Tay-Sachs and Sandhoff disease patients, due to genetic defect of lysosomal beta-hexosaminidase.


Catalog Number: (102988-408)
Supplier: Adipogen
Description: Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM3 is the most abundant ganglioside in mammals. It is involved in several tumor processes by interacting with receptors. It inhibits epidermal cell growth and blocks insulin receptor activity.


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