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Supplier: Enzo Life Sciences
Description: Cell-permeable, ATP-competitive, potent inhibitor of Chk2.

Supplier: Ambeed
Description: BML-277 Chk2 inhibitor 98%

Catalog Number: (89158-242)
Supplier: Enzo Life Sciences
Description: BML-277 is a highly selective inhibitor of Chk2 (IC50=15nM). It displays potent radioprotective activity and prevents apoptosis of human T cells subjected to ionizing radiation (EC50= 3-7.6µM). Useful tool for dissecting the role of Chk2 in cellular signaling.


Supplier: Promega Corporation
Description: Recombinant full-length human CHK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. CHK2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage.

SDS

Supplier: ALADDIN SCIENTIFIC CORPORATION
Description: AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.A checkpoint kinase inhibitor for Chk1 and Chk2

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Supplier: Adipogen
Description: SCH900776 is a selective Chk1 inhibitor with an IC(50) of 3nM. It shows 50-fold selectivity for Chk1 versus Chk2.

Catalog Number: (102987-224)
Supplier: Adipogen
Description: Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site. Cytotoxic and insecticidal. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor. Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins. MAP kinase kinase 1 (MEK-1) inhibitor. Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic. Potential anti-Alzheimer agent.


Supplier: Adipogen
Description: Antagonizing the Chk1-mediated cell cycle checkpoints has emerged as an attractive target for anticancer therapy. If Chk1 activity is blocked, DNA-damaged or spindle-disrupted cells would exit cell cycle arrest before full repair and subsequently undergo mitotic catastrophe or cell death. Chk1 inhibitors consequently increase the therapeutic index of DNA-damaging or antimitotic agents as well. PF-0477736 is a selective, potent ATP-competitive Chk1 inhibitor, derived from PF-0394691, inhibits Chk1 (Ki, 0.49nM) and Chk2 (Ki, 47nM) in vitro. In tests, PF-0477736 was identified as a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49nM. PF-0477736 abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin. In xenografts, PF-0477736 enhanced the antitumor activity of gemcitabine in a dose-dependent manner. PF-0477736 combinations were well tolerated with no exacerbation of side effects commonly associated with cytotoxic agents.

Supplier: Adipogen
Description: Checkpoint kinases CHK1 and CHK2 are activated in response to DNA damage that results in cell cycle arrest, allowing sufficient time for DNA repair. Agents that lead to abrogation of such checkpoints have potential to increase the efficacy of such compounds as chemo- and radiotherapies. AZD7762 is a specific inhibitor for the CHK1/2 kinases with IC(50) values less than 10. AZD7762 enhances radiation sensitivity and gemcitabine-mediated radiosensitization in pancreatic cancer cells and xenografts and thus is helpful in the treatments of potentially many cancers. In addition, AZD7762 is a chemosensitizer and with gemcitabine and radiation produced a significant delay in the growth of pancreatic tumor xenografts with tolerable toxicity. AZD7762 is being studied as an important link in improving both adjuvant therapy and the treatment of metastatic disease.

Catalog Number: (89304-266)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to Chk2 (Phospho Ser516)


Catalog Number: (89415-458)
Supplier: Prosci
Description: Chk2 Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. The checkpoint kinase Chk2 is the mammalian homologue of yeast Cds1/Rad53. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53. Chk2 serves as ATM downstream effector to mediate activation of p53. Chk2 also phosphorylates and activates BRCA1, the product of a tumor suppressor gene that is mutated in breast and ovarian cancer.


Catalog Number: (102109-364)
Supplier: Novus Biologicals
Description: The Chk2 Antibody (8F12) from Novus Biologicals is a mouse monoclonal antibody to Chk2. This antibody reacts with human. The Chk2 Antibody (8F12) has been validated for the following applications: Western Blot, Immunocytochemistry / Immunofluorescence.


Catalog Number: (220009-294)
Supplier: R&D Systems
Description: The Recombinant Human Active Chk2 Protein from R&D Systems is derived from Sf 9 (baculovirus). The Recombinant Human Active Chk2 Protein has been validated for the following applications: Bioactivity.


Catalog Number: (101649-350)
Supplier: MilliporeSigma
Description: Anti-CHK2 Mouse Monoclonal Antibody [clone: 7]

Blocked

Catalog Number: (89276-812)
Supplier: Genetex
Description: Rabbit polyclonal antibody to Chk2 (phospho Thr387)


Catalog Number: (103360-068)
Supplier: Novus Biologicals
Description: The Chk2 Antibody (73C175.1.1) from Novus Biologicals is a mouse monoclonal antibody to Chk2. This antibody reacts with human, mouse. The Chk2 Antibody (73C175.1.1) has been validated for the following applications: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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