You Searched For: Akt+inhibitor+VIII

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Akt inhibitor VIII ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Description: Potent inhibitor of Akt1, Akt2 and Akt3 activity.

Akt inhibitor VIII ≥95% (by HPLC), Calbiochem®

Catalog Number: (80016-856)

Supplier: MilliporeSigma

Description: Akti-1/2; 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one

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GSK-3β inhibitor VIII

Catalog Number: (AAJ64554-MA)

Supplier: Thermo Scientific Chemicals

Description: A cell-permeable, potent, and selective inhibitor of GSK-3beta

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GSK-3β inhibitor VIII 98%

Supplier: Ambeed

Description: 1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea, Purity: 98%, CAS Number: 487021-52-3, Appearance: Form: solid, Storage: Keep in dark place, Sealed in dry, 2-8 C, Size: 250mg

Histone Deacetylase Inhibitor VIII ≥98% (by TLC)

Supplier: Enzo Life Sciences

Description: HDAC6 inhibitor

Bisindolylmaleimide VIII·acetate ≥98% (by NMR)

Supplier: Adipogen

Description: Selective protein kinase C (PKC) inhibitor. Inhibits proliferation of cultured mouse epidermal keratinocytes. Enhances Fas- and TRAIL-mediated apoptosis. Inhibits T cell-mediated autoimmune diseases. Inhibits stimulation of insulin secretion by glucose. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2).

PJ-34 hydrochloride

Supplier: Thermo Scientific Chemicals

Description: A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase

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Histone Deacetylase Inhibitor VIII 98%

Catalog Number: (77163-180)

Supplier: Ambeed

Description: tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate, Purity: 98%, CAS Number: 1045792-66-2, Appearance: White to off white powder or crystals, Storage: Sealed in dry, Store in freezer, under -20 C, Size: 1mg

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Akt-I-1 ≥95%

Supplier: Adipogen

Description: The compound (Akt-I-1) inhibits only Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 isoform, AKT-I-1 blocked the phosphorylation and activation of AKT1 by PDK1 (phosphoinositide-dependent kinase 1). The inhibitor was found to be cell-active and to block phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells, block the phosphorylation of known Akt substrates and promote TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in LNCap prostate cancer cells.

Akt-I-2 hydrochloride ≥95%

Supplier: Adipogen

Description: The compound (Akt-I-2) inhibited both Akt1 and Akt2 with IC(50) values of 2.7 and 21 µM respectively. It does not inhibit AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 and AKT2 isoforms, AKT-I-1,2 blocked the phosphorylation and activation of AKT1 and AKT2 by PDK1 (phosphoinositide-dependent kinase 1). The inhibitor was found to be cell-active and to block phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells, block the phosphorylation of known Akt substrates and promote TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in LNCap prostate cancer cells.

DDR2 Kinase Enzyme System, Promega

Supplier: Promega Corporation

Description: Recombinant human DDR2 (467-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. DDR2 is a member of a novel subclass of RTKs containing a distinct extracellular region encompassing a factor VIII-like domain.

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Anti-NFKBIL1 Rabbit Polyclonal Antibody

Catalog Number: (103453-356)

Supplier: Affymetrix, Inc.

Description: Suggested positive control: HeLa. NF-kappa-B inhibitor-like protein 1 (NFKBIL1), also named Ikb like and IkbL1, is a 381 amino acid member of the inhibitor of NF-kappaB (IkappaB) family of proteins. NFKBIL1 contains two ANK repeats and is expressed in the rheumatoid synovial lining and sub-lining layers and co-localized in CD68+ and CD3+, but not Factor VIII+ cells. It is reported that defects in NFKBIL1 expression causes of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and affects the joints. Rheumatoid arthritis (RA) is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.