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6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyridine ≥98.0% (by HPLC, titration analysis)

Catalog Number: (TCB3034-5G)

Supplier: TCI America

Description: CAS Number: 92276-38-5
Molecular Formula: C5H3BrN4
Molecular Weight: 199.01
Purity/Analysis Method: >98.0% (HPLC,T)
Form: Crystal
Melting point (°C): 206

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4,5-Dimethoxy-2-methylaniline

Supplier: Matrix Scientific

Description: MF=C9H13No2 MW=167.21 Cas=41864-45-3 MDL=MFCD00130067 5G

6-Bromo-1H-imidazo[4,5-b]pyridin-2(3H)-one 95%

Supplier: Ambeed

Description: 6-Bromo-1H-imidazo[4,5-b]pyridin-2(3H)-one 95%

Description: AASTYs (Acrylic acid-co-styrenes) - like AASTY 6-45 - are highly alternating copolymers, well-suited for generating native lipid nanodiscs. They are a 2022 novel developed series for membrane protein solubilization & stabilization. AASTY 6-45 gets it's name from its molecular weight and Acrylic Acid : Styrene Ratio. These varying ratios of acrylic acid to styrene contribute to the hydrophilic properties of our AASTYs. In general lighter AASTYs, like 6-45 tend to be more aggressive, while heavier AASTYs, such as 11-45 show higher thermodynamic stability.

The exact composition of AASTY copolymers shows different extraction efficiency, depending on the lipid composition of the lipid bilayers being formulated into nanodiscs. As AASTY is made by controlled radical polymerization techniques, the dispersity of polymer molecular weight distribution is low, and the molecular weights are controlled. This means that excess AASTY copolymer can be removed by dialysis after nanodisc formation. Based on previous findings on SMA, it is the expectation that AASTY of different molecular weights will display different rates of nanodisc formation, extraction efficacy, and stability of resulting nanodiscs.

Every membrane protein solubilization needs to undergo a screening process before. The characteristic phospholipid environment surrounding the different membrane proteins in question performs differently well with each polymer. To support you in this process we offer a handy Screening Kit for AASTYs to test them all. Additionally, we recommend the two following publications if you would like to get further information: Smith et al. 2020 & Timcenko et al. 2022

(6-Bromo-3H-imidazo[4,5-b]pyridin-2-yl)methanol ≥97%

Catalog Number: (102841-990)

Supplier: Matrix Scientific

Description: (6-Bromo-3H-imidazo[4,5-b]pyridin-2-yl)methanol ≥97%

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4,5-Difluorobenzimidazole

Supplier: Matrix Scientific

Description: MF=C7H4F2N2 MW=154.12 Cas=236736-21-3 MDL=MFCD00153122 100Mg

4,5-Dicyanoimidazole ≥98.0% (by HPLC, total nitrogen)

Supplier: TCI America

Description: CAS Number: 1122-28-7
MDL Number: MFCD00005194
Molecular Formula: C5H2N4
Molecular Weight: 118.10
Purity/Analysis Method: >98.0% (HPLC,N)
Form: Crystal
Melting point (°C): 175

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