You Searched For: Cayman Chemical Company

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SC-514 ≥98%

Supplier: Cayman Chemical Company

Description: SC-514, Purity >/=98%, CAS 354812-17-2, MF: C9H8N2OS2, MW: 224.3, Synonyms: 4-amino-[2,3'-bithiophene]-5-carboxamide, selective and reversible inhibitor of IKB kinase 2, Formulation: A crystalline solid, Size: 10mg

Dimethyl biphenyl-4,4'-dicarboxylate ≥95%

Supplier: Cayman Chemical Company

Description: Dimethyl biphenyl-4,4'-dicarboxylate, Purity >/=95%, CAS 792-74-5, MF: C16H14O4, MW: 270.3, Synonyms: Biphenyl dimethyl dicarboxylate, 4,4'-dimethyl ester [1,1'-biphenyl]-4,4'-dicarboxylic acid, Size: 25g

Human Recombinant IRF3 (from E. coli)

Catalog Number: (76292-902)

Supplier: Cayman Chemical Company

Description: Interferon regulatory factor 3 (IRF3) is a member of the IRF family. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection, functioning as a molecular switch for antiviral activity. Double-stranded RNA generated during a viral infection leads to IRF3 activation by serine/threonine phosphorylation by TBK1 or IKBKE kinases, which induces a conformational change leading to its dimerization, nuclear localization, and association with CREBBP. The complex, known as DRAF1, activates transcription interferons alpha and beta, as well as other interferon-induced genes. These genes play a critical role in type 1 interferon (IFN)-dependent immune response. A recent study shows phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF recruits and specifies IRF3 phosphorylation and activation by the serine/threonine-protein kinase TBK1, thereby inducing the production of type-1 interferons.

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2-(5,6-Dimethyl-9-oxoxanthen-4-yl)acetic acid (DMXAA) ≥98%

Supplier: Cayman Chemical Company

Description: DMXAA, Purity >/=98%, CAS 117570-53-3, Molecular Formula: C17H14O4, Formula Weight: 282.3, Synonyms: ASA 404, 5,6-Dimethylxanthenone-4-acetic Acid, NSC 640488, Vadimezan, Formulation: A crystalline solid, Storage: -20C, Size: 25mg

Human Recombinant cGAS (from E. coli)

Catalog Number: (76292-892)

Supplier: Cayman Chemical Company

Description: Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates (STING), leading to activation of the type I interferon (IFN) pathway. In vitro, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS-/-) mice do not produce type I IFNs following DNA transfection or DNA virus infection. Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses. In vivo, cGAS-/- mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.

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Human Recombinant STING R232 viriant (from E. coli)

Catalog Number: (76293-148)

Supplier: Cayman Chemical Company

Description: Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN). The R232 variant is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} The SNP variant H232 (Item No. 22815) is found at a 13.7% frequency. Various mutations in STING either reduce or increase its activity. Gain-of-function mutations in STING, including R284M (Item No. 23594) and V155M, lead to constitutive activation and enhancement of the type I IFN response. The V155M mutation is associated with a systemic inflammatory condition, including pulmonary fibrosis and autoimmune factors. Mutations that reduce STING activity include K224R (Item No. 23593), which reduces ubiquitination of STING thereby disrupting its localization within the cell, and the double mutation G230A, R293Q (Item No. 23592), which reduces the IFN response. A T596A mutation present in the mouse strain Goldenticket leads to a complete loss of STING protein and lack of a type I IFN response to infection by Listeria.