You Searched For: Thapsigargin


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Supplier: Enzo Life Sciences
Description: ATPase inhibitor

Supplier: Adipogen
Description: Intracellular Ca2+ signaling probe. Specific and sensitive inhibitor of SERCA. Non-TPA/PMA tumor promoter. Histamine release inducer. Apoptosis inducer. Mitochondrial dysfunction inducer. NOS modulator. Angiogenesis inhibitor. Stimulator of arachidonic acid metabolism in macrophages. Autophagy inducer. TRAIL sensitizer.

Small Business Enterprise

Supplier: Thermo Scientific Chemicals
Description: Cell permeable sesquiterpene lactone tumor promoter. Inhibits endoplasmic reticulum calcium-ATPase
Catalog Number: (IC15899901)
Supplier: MP Biomedicals
Description: Thapsigargin may be used to distinguish between discrete intracellular Ca2+ pools. It induces apoptosis in rat thymocytes and in human hepatoma cells.

Catalog Number: (80055-474)
Supplier: MERCK, S.A. DE C.V. SV
Description: A cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50=4–13nM)

Supplier: Thermo Scientific Chemicals
Description: Thapsigargin 97%

Supplier: Ambeed
Description: Thapsigargin ≥99% (by HPLC)

New Product

Catalog Number: (103468-066)
Supplier: Affymetrix, Inc.
Description: Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of Bi-1. BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007).  BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli.  Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress–causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury.  Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER.   

Blocked

Catalog Number: (IC15377001)
Supplier: MP Biomedicals
Description: Ryanodine is used experimentally in conjunction with Thapsigargin and other inhibitors of Calcium ATPase uptake of calcium into Sarcoplasmic Reticulum.

SDS


Catalog Number: (103468-156)
Supplier: Affymetrix, Inc.
Description: MA1-41678 is derived from a mixture of three synthetic peptides corresponding to the N-terminal, internal and C-terminal regions of human B1.  Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of Bi-1. BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007).  BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli.  Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress–causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury.  Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER.   

Blocked

Catalog Number: (103476-312)
Supplier: Affymetrix, Inc.
Description: BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress.  BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli.  Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress–causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury.  Conversely, overexpression of BI-1<sup> </sup>protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca<sup>2+</sup> handling by the ER.   

Blocked

Catalog Number: (220228-269)
Supplier: Sigma Aldrich
Description: THAPSIGARGIN

Blocked

Catalog Number: (220228-268)
Supplier: Sigma Aldrich
Description: THAPSIGARGIN

Blocked

Catalog Number: (103375-810)
Supplier: Cell Signaling Technology
Description: 12758S THAPSIGARGIN-1 MG

Blocked

Catalog Number: (220228-267)
Supplier: Sigma Aldrich
Description: THAPSIGARGIN

Blocked

Catalog Number: (100507-240)
Supplier: R&D Systems
Description: THAPSIGARGIN 1MG


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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