Thapsigargin ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Thapsigargin ≥99% (by HPLC)

Thapsigargin ≥99% (by HPLC)

Synonyms: (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-Acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-(((Z)-2-methylbut-2-enoyl)oxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate

BML-PE180-0001 BML-PE180-0005

89161-410EA 97.01 USD

89161-410 89161-412

Thapsigargin ≥99% (by HPLC)

ATPase inhibitor

Cell permeable tumor promoter. Induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the (sarco)endoplasmatic reticulum Ca2+-ATPase (SERCA) (IC50=30nM). Inhibition of SERCA reveals a significant change in intracellular Ca2+ homeostasis and pH regulation in tumor cells. May be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of PKC activation. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Induces apoptosis. Stimulates nitric oxide (NO) production, contributing to hepatocyte apoptosis.

Formula: C₃₄H₅₀O₁₂
MW: 650.762 g/mol

MDL Number: MFCD00083511
CAS Number: 67526-95-8

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