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Anti-MUC1 Mouse Monoclonal Antibody (CF568) [clone: MUC1/967]

Supplier: Biotium
Description: This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Image Unavailable-BT138700-5G

Iridium(IV) oxide ≥99% (trace metals basis)

Supplier: BeanTown Chemical
Description: CAS: 12030-49-8; EC No: 234-743-9; MDL No: MFCD00011065 UN No: UN1479; Haz Class: 5.1; Packing Group: II Powder; Molecular Formula: IrO2; MW: 224.21

SDS

Image Unavailable-100201-742

(1,5-Cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate ≥99%

Supplier: Strem Chemicals Inc
Description: (Tricyclohexylphosphine)(1,5-cyclooctadiene)(pyridine)iridium (I) hexafluorophosphate,purity: Min 98%, CAS number: 64536-78-3, M F: C31H50F6IrNP2, Color: orange, Form: crystalline, Size: 0.05g

Image Unavailable-100205-196

Iridium(III) chloride hydrate ≥99.9% (Ir basis)

Supplier: Strem Chemicals Inc
Description: CAS #: 14996-61-3. Size: 5g.

Image Unavailable-BT137470-2G

(Pentamethylcyclopentadienyl)iridium(III) dichloride dimer

Supplier: BeanTown Chemical
Description: CAS: 12354-84-6; MDL No: MFCD00075435 Solid; Molecular Formula: C20H30Cl4Ir2; MW: 796.67

SDS

Image Unavailable-10800-290

Anti-AXIN2 Rabbit Polyclonal Antibody

Catalog Number: (10800-290)
Supplier: Rockland Immunochemical
Description: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Product Image-TS37795-0050

(Pentamethylcyclopentadienyl)iridium(III) dichloride dimer 99%

Supplier: Thermo Scientific Chemicals
Description: (Pentamethylcyclopentadienyl)iridium(III) dichloride dimer 99%

Image Unavailable-100210-082

Carbonylchlorobis(triphenylphosphine)iridium(I) ≥99%

Supplier: Strem Chemicals Inc
Description: CAS #: 14871-41-1. Size: 1g.

Image Unavailable-76195-736

Anti-MUC1 Mouse Monoclonal Antibody [clone: MUC1/967]

Catalog Number: (76195-736)
Supplier: Prosci
Description: This Epithelial Membrane Antigen / EMA antibody, also called MUC1 and Mucin-1, recognizes the full-length protein in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this mAb is APDTR in the VNTR region. It reacts with the core peptide of the EMA protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the mAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This EMA antibody reacts with both normal and malignant epithelia of various tissues including breast and colon.
Image Unavailable-10246-546

Anti-BEST2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10246-546)
Supplier: Bioss
Description: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.
Image Unavailable-10246-538

Anti-BEST2 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10246-538)
Supplier: Bioss
Description: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.
Image Unavailable-75963-654

Anti-MUC1 Mouse Monoclonal Antibody (CF640R) [clone: HMPV]

Supplier: Biotium
Description: This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Image Unavailable-75963-768

Anti-MUC1 Mouse Monoclonal Antibody (CF640R) [clone: MUC1/967]

Supplier: Biotium
Description: This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Image Unavailable-BT126325-1G

Iridium(IV) chloride ≥99.95% (trace metals basis)

Supplier: BeanTown Chemical
Description: CAS: 10025-97-5; EC No: 233-048-8; MDL No: MFCD00016155; RTECS: NO3610000 Pieces/Powder; Molecular Formula: IrCl4; MW: 334.01 Melting Point: <gt/>350° Hygroscopic

SDS

Image Unavailable-89050-400

Polysorbate 80 NF

Supplier: Spectrum Chemicals
Description: Polysorbate 80, NF is used to solubilize essential oils.

Certificates

Image Unavailable-10246-542

Anti-BEST2 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10246-542)
Supplier: Bioss
Description: The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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