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Catalog Number: (76733-774)
Supplier: ANTIBODIES.COM LLC
Description: Rat PDE5A/PDE5 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of rat PDE5A/PDE5 in serum, plasma, tissue homogenates, and other biological fluids.


Catalog Number: (76737-866)
Supplier: ANTIBODIES.COM LLC
Description: Mouse PDE5A/PDE5 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of mouse PDE5A/PDE5 in serum, plasma, tissue homogenates, and other biological fluids.


Catalog Number: (76739-832)
Supplier: ANTIBODIES.COM LLC
Description: Human PDE5A/PDE5 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human PDE5A/PDE5 in serum, plasma, tissue homogenates, and other biological fluids.


Catalog Number: (10165-630)
Supplier: Genetex
Description: Rabbit polyclonal antibody to PDE5 (phospho Ser92)


Supplier: Ambeed
Description: PDE5-IN-7 95%

New Product

Catalog Number: (89367-374)
Supplier: Genetex
Description: The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP]) are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of G protein coupled receptors (GPCRs) for hormones, cytokines, and neurotransmitters. Cyclic nucleotides are important intracellular second messengers which play important role in a variety of signal transduction process. The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. One of the many phosphodiesterases that compartmentalized and hydrolyze cGMP in various tissues is phosphodiesterase type 5A. The cGMP is involved in nitric oxide signaling as well as cell signaling associated with natriuretic peptides and gulanylins. Some of the intracellular biding cites for the cGMP include cyclic nucleotide gated ion channels, cGMP dependent protein kinases, and cyclic GMP biding phosphodiesterases (cGB PDEs). The cGB PDEs include PDE2, PDE3, PDE5, PDE5 and PDE10; the members of these families contain various structural and functional motifs that are conserved. Most of these proteins contain dimmeric subunits that contain a highly conserved cGMP binding site and a phosphodiesterase catalytic site.


Catalog Number: (89367-362)
Supplier: Genetex
Description: One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N-terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP; it is sensitive to non-selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP-specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis.


Supplier: TCI America
Description: 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyrimidinone, Purity: >98.0%(HPLC)(T), CAS Number: 139756-21-1, Molecular Formula: C17H20N4O2, MW: 312.37, Size: 5G

Catalog Number: (89367-360)
Supplier: Genetex
Description: One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N-terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP; it is sensitive to non-selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP-specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis.


Supplier: ALADDIN SCIENTIFIC CORPORATION
Description: Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.

New Product

Catalog Number: (76171-628)
Supplier: Boster Biological Technology
Description: Rabbit IgG polyclonal antibody for cGMP-specific 3',5'-cyclic phosphodiesterase(PDE5A) detection. Tested with WB, IHC-P in Human;Rat.


Supplier: Adipogen
Description: Purine alkaloid related to caffeine. Potent antioxidant. Not through direct scavenging of ROS but strengthen antioxidant systems in vivo. Anti-inflammatory and antinociceptive compound. Suggested to have adenosine receptor agonistic activity and also acting on dopamine receptors. Shown to have potent sedative and hypnotic properties. Ameliorated learning and memory impairments caused by central fatigue. Shown to inhibit cAMP-specific PDE4 and cGMP-specific PDE5 activity in vivo and in vitro. Increased glucose level, decreased lactic acid concentration, reduced LDH activity and elevated the expressions of both GLUT1/3 in restraint-stressed mice. Can increase the solubility of aromatic systems in water.

Catalog Number: (103732-372)
Supplier: Affymetrix, Inc.
Description: PAB RABBIT PDE5 HUMAN RAT IGG 100UG F/WB

Blocked

Catalog Number: (101745-284)
Supplier: Cell Signaling Technology
Description: 2395S PDE5 ANTIBODY-100 UL

Blocked

Catalog Number: (101747-902)
Supplier: Cell Signaling Technology
Description: 3585S PDE5 (P434) ANTIBODY-100 UL

Blocked

Catalog Number: (MSPP-AB56614)
Supplier: Abcam
Description: PROTEIN RECOMBINAT PDE5A/PDE5 HUMAN 10UG

New Product


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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