You Searched For: PD-0173074

Supplier: Strem Chemicals Inc

Description: 99+% (99.95+%-Pd)

Catalog Number: (76634-554)

Supplier: Diagnostic Biosystems

Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.

Supplier: Thermo Scientific Chemicals

Description: MDL: MFCD00049788

SDS Certificates

Supplier: AAT BIOQUEST INC

Description: PD-10 Buffer Reservoir provides an easy and rapid way for equilibrating PD-10 columns.

Catalog Number: (ABCA_AB244081-10X9)

Supplier: Abcam

Description: Mouse PD-1H antibody pair - BSA and Azide free.

New Product

Supplier: Thermo Scientific Chemicals

SDS Certificates

Catalog Number: (75843-268)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.

Catalog Number: (76163-706)

Supplier: Prosci

Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.

Catalog Number: (76163-704)

Supplier: Prosci

Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.

Supplier: Strem Chemicals Inc

Description: CAS #: 13601-08-6. Size: 50g.

Catalog Number: (75843-272)

Supplier: BIOGEMS INTERNATIONAL INC.

Description: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.

Supplier: Ambeed

Description: Tetrakis(triphenylphosphine)palladium(0) 98%

Catalog Number: (AA10006-03)

Supplier: Thermo Scientific Chemicals

Description: Soluble in acetone, chloroform

SDS Certificates

Catalog Number: (103294-702)

Supplier: Novus Biologicals

Description: The PD-1 Antibody (913425) [DyLight 550] from Novus Biologicals is a mouse monoclonal antibody to PD-1. This antibody reacts with human. The PD-1 Antibody (913425) [DyLight 550] has been validated for the following applications: Flow Cytometry.

Catalog Number: (103294-700)

Supplier: Novus Biologicals

Description: The PD-1 Antibody (913425) [DyLight 405] from Novus Biologicals is a mouse monoclonal antibody to PD-1. This antibody reacts with human. The PD-1 Antibody (913425) [DyLight 405] has been validated for the following applications: Flow Cytometry.

Supplier: Diagnostic Biosystems

Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.