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SANT-2 ≥95% (by NMR)

Supplier: Adipogen
Description: Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.

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Trifluoroacetic acid-[D₁] 99.5 atom % D for NMR spectroscopy

Catalog Number: (TS325330100)
Supplier: Thermo Scientific Chemicals
Description: Packaged in 1 ml ampoules

New Product


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Bisindoylmaleimide X hydrochloride ≥98% (by NMR)

Supplier: Adipogen
Description: Selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Inhibits superoxide generation in human neutrophils.

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YC-1 ≥98% (by NMR)

Supplier: Adipogen
Description: Nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator. Induces concentration-dependent increase in cGMP levels. Inhibits platelet adhesion to collagen. Thombosis inhibitor. Non-specific phosphodiesterase inhibitor. Na+ channel blocker. Anticancer compound. HIF-alpha inhibitor. Blocks angiogenesis. Tumor growth inhibitor. Apoptosis inducer. NK cell differentiation enhancer. TRAIL sensitizer.

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Chloroform-[D₁] (99.8% D) +0.05% V/V TMS for NMR spectroscopy

Supplier: Cambridge Isotope Labs Inc
Description: Contains 0.05% TMS.

SDS

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MS-275 ≥98% (by NMR)

Supplier: Adipogen
Description: HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Review. Promotes either self-renewal or differentiation of embryonic stem cells.

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Pifithrin-alpha·hydrobromide ≥98% (by NMR)

Supplier: Adipogen
Description: p53 inhibitor. Reversibly blocks p53-dependent transcriptional activation. Tool to combat side effects of cancer therapy. Apoptosis inhibitor.

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Propionyl-L-carnitine hydrochloride ≥98% (by NMR)

Supplier: Adipogen
Description: Naturally occurring carnitine derivative formed by carnitine acetyltransferase during beta-oxidation of uneven chain fatty acids, with high affinity for muscular carnitine transferase. Increases cellular carnitine content, allowing free fatty acid transport into the mitochondria. Stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activity. Important for mitochondrial metabolism and energy regulation. Regulates the metabolism of both carbohydrates and lipids, leading to an increase of ATP generation. Selectively inhibits in vitro and ex vivo platelet-activating factor (PAF) synthesis from human neutrophils. Antioxidant. Shows free radical scavenging activity. Decreases the expression of inducible nitric oxide synthase (iNOS/NOS II) and NADPH-oxidase 4-mediated reactive oxygen species production in human umbilical vascular endothelial cells. Shows beneficial cardiovascular effects. Improves body weight, food intake, adiposity and insulin resistance in Type 2 diabetes. Stimulates endothelial nitric oxide (eNOS/NOS III) and increased NO production, via AMPK/Src-mediated signaling that leads to activation of PI3 kinase and Akt.

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Apcin ≥95% (by NMR)

Catalog Number: (102988-736)
Supplier: Adipogen
Description: Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition.
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N-Dodecanoyl-L-homoserine lactone ≥98% (by NMR)

Supplier: Adipogen
Description: N-Dodecanoyl-L-homoserine lactone (C12-HSL) is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-kappaB in RAW 264.7 macrophages, increasing the expression of TNF-alpha, interleukin-1beta (IL-1beta) and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. It is important to note that C12-HSL is distinct from N-3-oxo-dodecanoyl-L-homoserine lactone, which is produced at different times in biofilm development and has different cellular effects.

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BAY 43-9006 ≥98% (by NMR)

Supplier: Adipogen
Description: Antitumor compound. Broad-spectrum kinase inhibitor. Raf kinase inhibitor. Apoptosis inducer. Cytostatic. Angiogenesis inhibitor. Review.

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Diethyl ether-[D₁₀] (99% D) (Isotopic) for NMR spectroscopy

Catalog Number: (AA42282-03)
Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00062316

SDS Certificates


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7-Hydroxy-4-(trifluoromethyl)coumarin

Supplier: Adipogen
Description: This compound is widely used as a substrate for Cytochrome P450. It has also been used as a marker substrate for assessment of Drug-Drug interactions to multiple isoforms of UDP-glucuronosyltransferases. Suitable as pH-indicator. Trifluoromethylumbelliferone is a slightly longer wavelength analog of 4-methylcoumarin (4-MU) with a pKa that more closely matches physiological pH values.

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Dimethyl sulfoxide-[D₆] (99.9% D) (Isotopic) for NMR spectroscopy

Catalog Number: (AA36517-46)
Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00002090

SDS Certificates


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3,3'-Dipropylthiacarbocyanine iodide

Supplier: Adipogen
Description: Carbocyanine dyes, particularly thiacyanines such as DiSC3(3) can inhibit respiration and may therefore be relatively cytotoxic. 3,3'-dipropyl-thiadicarbocyanine iodide is sensitive to membrane potential, fluorescence response to depolarization depends on the staining concentration and detection method. Selected applications are: -Calcium channels and other ion transport systems -Mitochondrial activity -Neurons and brain tissue -Membrane potential in intact yeast cells

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FK-866 ≥98% (by NMR)

Supplier: Adipogen
Description: Nampt/visfatin inhibitor. Inhibitor of NAD+ biosynthesis. Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4 nM and Ki = 0.3 nM, respectively). Apoptosis inducer. Autophagy inducer. Causes premature senescence. Angiogenesis inhibitor.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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