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Microplate Shakers, Boekel Scientific

Supplier: Boekel

Description: The Boekel Scientific Microplate Shaker features a low profile and small footprint and are available in a 2 Plate or 4 Plate Model

Accessories for VORTEX 3 Orbital Shakers

Supplier: IKA Works

Description: Accessories for VORTEX 3 Orbital Shakers

VORTEX 3 Orbital Shakers, 230 V

Catalog Number: (33993-876)

Supplier: IKA Works

Description: Orbital shakers are suitable for touch-operated or short-time continuous operation

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CO₂ Resistant Shakers, Thermo Scientific

Supplier: Thermo Fisher Scientific

Description: Get reliable around-the-clock operation ideally suited to keep your cells alive and flourishing within your working environment with Thermo Scientific™ CO₂ Resistant Shakers.

Anti-CRTC1 Rabbit Polyclonal Antibody

Catalog Number: (10078-902)

Supplier: Prosci

Description: MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1, Transducer of regulated cAMP response element-binding protein 1, TORC1, and Transducer of CREB protein 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.

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Anti-PDGFA + PDGFB Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10274-784)

Supplier: Bioss

Description: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008].

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Roto-Shake Genie™ 6–in–1 Multi-Purpose Rotator Rocker, Scientific Industries

Catalog Number: (58815-176)

Supplier: Scientific Industries

Description: Space-saving multi-action platform rotator/rocker produces six different mixing motions: rotating, rotating/rocking, rotating/rolling, rolling/rocking, and rocking/shaking, as well as a combination of all of these.

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Anti-LDLR Chicken Polyclonal Antibody

Catalog Number: (75929-568)

Supplier: Rockland Immunochemical

Description: The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.